Mesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model

  • Kazim Sahin
  • Cemal Orhan
  • Fatih Akdemir
  • Mehmet Tuzcu
  • Nurhan Sahin
  • Ismet Yilmaz
  • Shakir Ali
  • Jayant Deshpande
  • Vijaya Juturu
Keywords: High-fat diet, insulin resistance, liver, mesozeaxanthin, rats

Abstract

Background: Mesozeaxanthin (MZ) is a macular carotenoid which has been reported to have a number of pharmacological properties, including the antioxidant, and anticarcinogenic property, and has been stated to decrease the hepatocyte lipid content.

Objective: In this study, we investigated the effect of MZ on cardio-metabolic health risk (CMHR) and its probable mechanisms of action in rats fed a high-fat diet (HFD).

Design: Rats were randomly divided into four groups consisting of (i) Control, (ii) MZ, (iii) HFD, and (iv) HFD+MZ.

Results: MZ treatment increased the antioxidant enzyme activities and helped improve the liver function. The treatment alleviated CMHR and decreased the level of nuclear factor kappa B (NF-κB p65) and tumor necrosis factor-alpha (TNF-α). The levels of hepatic peroxisome proliferator-activated receptor gamma (PPAR-γ), phosphorylated insulin receptor substrate 1 (p-IRS-1), β,β-carotene 9’,10’-oxygenase 2 (BCO2) and nuclear factor erythroid 2-related factor 2 (Nrf2), which decrease in HFD rats, were found to be significantly higher in MZ supplemented animals.

Conclusion: MZ has antioxidant and anti-inflammatory properties and can is reported in this study toprotect against fatty liver and cardio-metabolic syndrome, possibly through regulation of PPAR-γ, IRS-1, Nrf2 and NF-κB proteins, in an insulin-resistant rodent model.

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Published
2017-07-18
How to Cite
Sahin, K., Orhan, C., Akdemir, F., Tuzcu, M., Sahin, N., Yilmaz, I., Ali, S., Deshpande, J., & Juturu, V. (2017). Mesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model. Food & Nutrition Research, 61. Retrieved from http://foodandnutritionresearch.net/index.php/fnr/article/view/1253
Section
Original Articles