@article{González-Torres_Matos_Vázquez-Velasco_Santos-López_Sánchez- Martínez_García–Fernández_Bastida_Benedí_Sánchez-Muniz_2016, title={Glucomannan- and glucomannan plus spirulina-enriched pork affect liver fatty acid profile, LDL receptor expression and antioxidant status in Zucker fa/fa rats fed atherogenic diets}, volume={61}, url={https://foodandnutritionresearch.net/index.php/fnr/article/view/1148}, abstractNote={<p>We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP)<br>on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/<br>fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC<br>(cholesterol-enriched control), HG and HGS (cholesterol-enriched glucomannan and glucomannan/<br>spirulina-RP) experimental diets were tested. Increased metabolic syndrome markers were<br>found in C, G and GS rats. Cholesterol feeding increased liver size, fat, and cholesterol and<br>reduced antioxidant enzyme levels and expressions. Cholesterolemia was lower in HG and HGS<br>than in HC. GS vs. G showed higher stearic but lower oleic levels. SFA and PUFA decreased while<br>MUFA increased by cholesterol feeding. The arachidonic/linoleic and docosahexaenoic/alphalinolenic<br>ratios were lower in HC, HG, and HGS vs. C, G, and GS, respectively, suggesting a<br>delta-6-elongase-desaturase system inhibition. Moreover, cholesterol feeding, mainly in HGS,<br>decreased low-density-lipoprotein receptor expression and the delta-5-desaturase activity and<br>increased the delta-9-desaturase activity. In conclusion, the liver production of highly unsaturated<br>fatty acids was limited to decrease their oxidation in presence of hypercholesterolaemia.<br>Glucomannan or glucomannan/spirulina-RP has added new attributes to their functional properties<br>in meat, partially arresting the negative effects induced by high-fat-high-cholesterol feeding<br>on the liver fatty acid and antioxidant statuses.</p&gt;}, journal={Food & Nutrition Research}, author={González-Torres Laura and Matos Cátia and Vázquez-Velasco Miguel and Santos-López Jorge A. and Sánchez- Martínez Iria and García–Fernández Camino and Bastida Sara and Benedí Juana and Sánchez-Muniz Francisco J.}, year={2016}, month={Dec.} }