TY - JOUR AU - Gooda Sahib Jambocus , Najla AU - Ismail , Amin AU - Khatib , Alfi AU - Mahomoodally , Fawzi AU - Saari , Nazamid AU - Waseem Mumtaz , Muhammad AU - Abdul Hamid , Azizah PY - 2017/07/27 Y2 - 2024/03/28 TI - <em>Morinda citrifolia</em> L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet JF - Food & Nutrition Research JA - fnr VL - 61 IS - 0 SE - Original Articles DO - UR - https://foodandnutritionresearch.net/index.php/fnr/article/view/1225 SP - AB - Background : Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile.Design : Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. 1 H NMR and LCMS methods were employed for phytochemical profiling of MLE60.Results : The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels . MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors . 1 Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant.Conclusion : MLE60 shows promise as an anti-obesity agents and warrants further research. ER -