TY - JOUR AU - Lei , Liu AU - Xiaoyi , Sui AU - Fuchang , Li PY - 2017/07/06 Y2 - 2024/03/28 TI - Effect of dietary copper addition on lipid metabolism in rabbits JF - Food & Nutrition Research JA - fnr VL - 61 IS - 0 SE - Original Articles DO - UR - https://foodandnutritionresearch.net/index.php/fnr/article/view/1250 SP - AB - The present study was conducted to investigate the effect of copper supplementation on lipidmetabolism in rabbits. Our study showed dietary copper addition (5-45 mg/kg) increased bodymass gain, but decreased fat and liver weights compared with those in the control group (P <0.05). Copper (45 mg/kg) addition significantly increased the skeletal muscle weight, but inhibitedcytoplasmic lipid accumulation in liver, skeletal muscle and adipose tissue (P < 0.05). Comparedwith the control group, dietary copper addition (45 mg/kg) significantly increased plasmatriglyceride levels but decreased very low density lipoprotein levels (P < 0.05). Copper treatmentsignificantly increased gene expression of carnitine palmitoyltransferase (CPT) 1, CPT2 andperoxisome proliferator-activated receptor (PPAR) a in liver (P < 0.05). In skeletal muscle, CPT1,CPT2, fatty acid transport protein, fatty acid-binding protein, and PPARa mRNA as well asphosphorylated AMP-activated protein kinase (AMPK) levels were significantly up-regulated bycopper treatment (P < 0.05). Rabbits receiving copper supplementation had higher CPT1, CPT2,PPARa and hormone-sensitive lipase mRNA levels in adipose tissue (P < 0.05). In conclusion,copper promoted skeletal muscle growth and reduced fat accretion. PPARa signaling in liver,skeletal muscle and adipose tissues and AMPK signaling in skeletal muscle tissue were involved inthe regulation of lipid metabolism by copper. ER -