@article{Jiang_Fu_Liu_Guo_Su_2018, title={Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats}, volume={62}, url={https://foodandnutritionresearch.net/index.php/fnr/article/view/1446}, DOI={10.29219/fnr.v62.1446}, abstractNote={<p><strong>Background</strong>: Chitooligosaccharide (COS) has shown potential antihyperlipidemic activity in a few studies as<br>a functional food.</p> <p><strong>Method</strong>: We investigated the cholesterol-lowering effect and potential mechanisms of chitooligosaccharide<br>capsules (COSTC) in male SD rats fed a high-fat diet.</p> <p><strong>Results</strong>: COSTC could ameliorate serum lipid levels. Simultaneously, the cholesterol-lowering effect is probably<br>attributed to its role in two pathways: upregulating the gene expression and activity of cholesterol 7α-hydroxylase (CYP7A1), liver X receptor alpha (LXRA), and peroxisome proliferation activated receptor-α (PPARα), which facilitates the conversion of cholesterol into bile acid; downregulating the gene expression and activity of enzymes including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) and upregulating the low-density lipoprotein receptor (LDLR) to reduce the denovo synthesis of cholesterol.</p> <p><strong>Conclusion</strong>: Studies have suggested that COSTC has potential usefulness as a natural supplement or functional food for preventing and treating hyperlipidemia.</p&gt;}, journal={Food & Nutrition Research}, author={Jiang Yao and Fu Chuhan and Liu Guihua and Guo Jiao and Su Zhengquan}, year={2018}, month={Jun.} }