@article{Liu_Huang_Li_Zhang_Zheng_2019, title={Suppressive effect of glycyrrhizic acid against lipopolysaccharideinduced neuroinflammation and cognitive impairment in C57 mice via toll-like receptor 4 signaling pathway}, volume={63}, url={https://foodandnutritionresearch.net/index.php/fnr/article/view/1516}, DOI={10.29219/fnr.v63.1516}, abstractNote={<p><strong>Background</strong>: Glycyrrhizinic acid (GA), a major active ingredient enriched in the roots of licorice, possesses well-confirmed anti-inflammatory effects.</p> <p><strong>Objective</strong>: To evaluate the underlying mechanisms of GA against lipopolysaccharide (LPS)-induced chronic neuroinflammation and memory impairment.</p> <p><strong>Design</strong>: We explored to investigate the effects of GA on neuroinflammation and memory impairment in an LPS-induced Alzheimer’s mouse model.</p> <p><strong>Results</strong>: Data of micro-PET/CT imaging and morris water maze test suggested that GA, when administrated orally, could reverse LPS-induced abnormalized glucose intake and metabolism in the brain and alleviate LPS-induced memory loss and cognitive defects in mice. Histological and immunohistochemical staining results revealed that GA treatment suppressed overexpressions of pro-inflammatory cytokines of IL-1 β and TNF-α in the brain of C57 mice by inhibiting toll-like receptor 4 (TLR4) signaling pathway activation.</p> <p><strong>Conclusion</strong>: Our findings suggest that GA may be a therapeutic agent for the treatment of neuroinflammation and cognitive impairment.</p&gt;}, journal={Food & Nutrition Research}, author={Liu Wenfeng and Huang Shun and Li Yonglian and Zhang Kun and Zheng Xi}, year={2019}, month={Apr.} }