@article{Shih_Chen_Varga_Shih_Chen_Lo_Shyur_Li_2020, title={White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice}, volume={64}, url={https://foodandnutritionresearch.net/index.php/fnr/article/view/3609}, DOI={10.29219/fnr.v64.3609}, abstractNote={<p><strong>Background</strong>: White sweet potato (WSP) has many potential beneficial effects on metabolic control and on diabetes- related insulin resistance. The antihyperglycemic effects of Tainung No. 10 (TNG10), a variety of WSP in Taiwan, warrant investigation.</p> <p><strong>Objective</strong>: To investigate the antidiabetic activity of WSP (Ipomoea batatas L. TNG10) and the mechanisms for interventions using whole leaves or tubers of WSP in diabetic mice.</p> <p><strong>Design</strong>: Mice were co-administered with streptozotocin and nicotinamide to induce diabetes and then treated with an experimental diet including either 10% WSP tuber (10%-T) and 30% WSP tuber (30%-T) or 0.5% WSP leaf (0.5%-L) and 5% WSP leaf (5%-L). After 8 weeks’ treatment, their plasma glycemic parameters, lipid profiles, and inflammatory marker were analyzed. Their pancreases were removed for histopathologic image analysis; proteins were also extracted from their muscles for phosphoinositide 3-kinase pathway analysis.</p> <p><strong>Results</strong>: The 30%-T or 5%-L mice had lower plasma glucose, insulin, glucose area under the curve (AUC), homeostatic model assessment of insulin resistance (HOMA-IR), alanine transaminase, triglyceride, and tumor necrosis factor alpha levels. In all diabetic mice, their Langerhans’s area was reduced by 60%; however, after 30% WSP-T or 5% WSP-L diets, the mice demonstrated significant restoration of the Langerhans’s areas (approximately 30%). Only in 5%-L mice, slightly increased expression of insulin-signaling pathway-related proteins, phosphorylated insulin receptor and protein kinase B and membrane glucose transporter 4 was noted.</p> <p><strong>Conclusions</strong>: WSP has antihyperglycemic effects by inducing pancreatic islet regeneration and insulin resistance amelioration. Therefore, WSP has potential applications in dietary diabetes management.</p&gt;}, journal={Food & Nutrition Research}, author={Shih Chun-Kuang and Chen Chiao-Ming and Varga Viola and Shih Liang-Chen and Chen Peng-Ru and Lo Shu-Fang and Shyur Lie-Fen and Li Sing-Chung}, year={2020}, month={Mar.} }