@article{Zhang_Li_Ying_Zhao_Yi_Li_Liu_2020, title={Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors}, volume={64}, url={https://foodandnutritionresearch.net/index.php/fnr/article/view/3677}, DOI={10.29219/fnr.v64.3677}, abstractNote={<p><strong>Background</strong>: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals.</p> <p><strong>Objective</strong>: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Design: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized.</p> <p><strong>Results</strong>: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation.</p> <p><strong>Conclusions</strong>: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients.</p&gt;}, journal={Food & Nutrition Research}, author={Zhang Jian and Li Wenhui and Ying Zhiwei and Zhao Di and Yi Guofu and Li He and Liu Xinqi}, year={2020}, month={Jun.} }