@article{Goh_Choi_2022, title={Genetic variation rs1121980 in the fat mass and obesity-associated gene (<em>FTO</em>) is associated with dietary intake in Koreans}, volume={66}, url={https://foodandnutritionresearch.net/index.php/fnr/article/view/8059}, DOI={10.29219/fnr.v66.8059}, abstractNote={<p style="color: #000000; font-family: ’Times New Roman’; font-size: medium; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong><em>Background:</em></strong>&nbsp;Fat mass and obesity-associated gene (<em>FTO</em>) is a well-known gene associated with body weight and obesity risk. Recent studies have suggested that genetic variations in&nbsp;<em>FTO</em>&nbsp;may play a role in the regulation of food preference and consumption. However, little is known with respect to Asian populations.</p> <p style="color: #000000; font-family: ’Times New Roman’; font-size: medium; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong><em>Objective:</em></strong>&nbsp;This study examined whether rs1121980 C &gt; T in&nbsp;<em>FTO</em>&nbsp;is associated with food intake in Koreans.</p> <p style="color: #000000; font-family: ’Times New Roman’; font-size: medium; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong><em>Design:</em></strong>&nbsp;This study was performed using data from the Korean Genome and Epidemiology Study (Ansan/Ansung cohort). Dietary intake was determined using the semi-food frequency questionnaire, and the&nbsp;<em>FTO</em>&nbsp;rs1121980 genotypes of 6,262 individuals (3,049 males and 3,213 females) were analyzed along with sex and body mass index (BMI).</p> <p style="color: #000000; font-family: ’Times New Roman’; font-size: medium; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong><em>Result:</em></strong>&nbsp;Genetic variation did not show a significant association with the population’s energy-nutrient intake. However, female T allele carriers with BMI ≥ 25 consumed more blue fish and coffee, and their coffee creamer consumption was decisively higher than that of T allele non-carriers (<em>P</em><sub>adjusted</sub>&nbsp;= 0.004). In males, the presence of the T allele showed a putative association with the consumption of sweets, snacks, and coffee creamer by the BMI level.</p> <p style="color: #000000; font-family: ’Times New Roman’; font-size: medium; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><strong><em>Conclusion:</em></strong>&nbsp;The&nbsp;<em>FTO</em>&nbsp;rs1121980 variation was associated with a preference for foods particularly high in fat (e.g. coffee creamer, blue fish, sweets, and snacks) in Koreans; these preferences varied by sex and BMI.</p&gt;}, journal={Food & Nutrition Research}, author={Goh Young and Choi Jeong-Hwa}, year={2022}, month={Nov.} }