TY - JOUR AU - Zhao , Huandong AU - Li , Jian AU - Zhao , Juan AU - Chen , Yang AU - Ren , Caiping AU - Chen , Yuxiang PY - 2018/04/20 Y2 - 2024/03/28 TI - Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose JF - Food & Nutrition Research JA - fnr VL - 62 IS - 0 SE - Original Articles DO - 10.29219/fnr.v62.1371 UR - https://foodandnutritionresearch.net/index.php/fnr/article/view/1371 SP - AB - Background: Many plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract.Objective: To investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal.Design: 70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks. Total antioxidant capacity (T-AOC), super dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, liver and brain were determined. The expression of Heme Oxygenase (HO-1), iNOS and Klotho in liver and brain were obtained.Results: WOC could improve the pathologic lesions caused by oxidative stress and significantly enhance the T-AOC, increase the activities of SOD, GSH-Px and decrease the contents of MDA in serum, liver and brain. Also, the WOC could obviously up-regulate the expression of HO-1 and Klotho and down-regulate the expression of iNOS.Conclusion: WOC can be used as an anti-aging food for its effectively eliminating free radicals, enhancing the antioxidant capacity and alleviating the damages of oxidative stress. ER -