Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

  • Vincenzo Nobile Farcoderm Srl member of Complife group, Via Mons. Angelini, 21, 27028 San Martino Siccomario, Pavia, Italy
  • Elisa Duclous Compagnie des Pêches Saint-Malo Santé, 35400 Saint Malo, France
  • Angela Michelotti Farcoderm Srl member of Complife group, Via Mons. Angelini, 21, 27028 San Martino Siccomario, Pavia, Italy
  • Gioia Bizzaro Farcoderm Srl member of Complife group, Via Mons. Angelini, 21, 27028 San Martino Siccomario, Pavia, Italy
  • Massimo Negro Laboratory of Pharmacobiochemistry, Sports Nutrition and Nutriceuticals, University of Pavia, Via A. Ferrata, 9, 27100 Pavia, Italy
  • Florian Soisson Compagnie des Pêches Saint-Malo Santé, 35400 Saint Malo, France
Keywords: Blue whiting, Fish protein hydrolysate, Body weight, Cholecystokinin, Glucagon-like peptide-1, Body composition, Clinical study, Weight management

Abstract

Background: Fish protein hydrolysates (FPHs) have been reported as a suitable source of proteins for human nutrition because of their balanced amino acid composition and positive effect on gastrointestinal absorption.

Objective: Here, we investigated the effect of a FPH, Slimpro®, obtained from blue whiting (Micromesistius poutassou) muscle by enzymatic hydrolysis, on body composition and on stimulating cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) secretion.

Design: A randomized clinical study was carried out on 120, slightly overweight (25 kg/m2 ≤ BMI<30 kg/m2), male (25%) and female (75%) subjects. FPH was tested in a food supplement at two doses (1.4 and 2.8 g) to establish if a dose–effect relationship exists. Product use was associated with a mild hypocaloric diet (−300 kcal/day). Body composition (body weight; fat mass; extracellular water; and circumference of waist, thighs, and hips) and CCK/GLP-1 blood levels were measured at the beginning of the study and after 45 and 90 days of product use. CCK/GLP-1 levels were measured since they are involved in controlling food intake.

Results: Treated subjects reported an improvement of body weight composition and an increased blood concentration of both CCK and GLP-1. No differences were found between the 1.4 and 2.8 g FPH doses, indicating a plateau effect starting from 1.4 g FPH.

Conclusions: Both 1.4 and 2.8 g of FPH were effective in improving body composition and in increasing CCK and GLP-1 blood levels.

Keywords: blue whiting; fish protein hydrolysate; body weight; cholecystokinin; glucagon-like peptide-1; body composition; clinical study; weight management

(Published: 29 January 2016)

Citation: Food & Nutrition Research 2016, 60: 29857 - http://dx.doi.org/10.3402/fnr.v60.29857

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Published
2016-01-29
How to Cite
1.
Nobile V, Duclous E, Michelotti A, Bizzaro G, Negro M, Soisson F. Supplementation with a fish protein hydrolysate (<em>Micromesistius poutassou</em&gt;): effects on body weight, body composition, and CCK/GLP-1 secretion. fnr [Internet]. 2016Jan.29 [cited 2019Nov.17];600. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/1053
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Original Articles