Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo

  • Wei Kevin Zhang South-Central University for Nationalities
  • Shan-Shan Tao
  • Ting-Ting Li
  • Yu-Sang Li
  • Xiao-Jun Li
  • He-Bin Tang South-Central University for Nationalities
  • Ren-Huai Cong Functional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinitus (China) Company Ltd.
  • Fang-Li Ma Functional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinitus (China) Company Ltd.
  • Chu-Jun Wan Oil Crops Research Institute, Chinese Academy of Agricultural Sciences
Keywords: Nutmeg oil, chronic pain, allodynia, COX-2, substance P

Abstract

Background: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain.

Methods and Results: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree.

Conclusions: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.

Keywords: nutmeg oil; chronic pain; allodynia; COX-2; substance P

(Published: 26 April 2016)

Citation: Food & Nutrition Research 2016, 60: 30849 - http://dx.doi.org/10.3402/fnr.v60.30849

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Published
2016-04-26
How to Cite
1.
Zhang W, Tao S-S, Li T-T, Li Y-S, Li X-J, Tang H-B, Cong R-H, Ma F-L, Wan C-J. Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release <em>in vivo</em&gt;. fnr [Internet]. 2016Apr.26 [cited 2019May19];600. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/1020
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Original Articles