Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model

Osman Bilgin Gulcicek; Kamil Ozdogan; Ali Solmaz; Hakan Yigitbas; Serdar Altınay; Aysegul Gunes; Duygu Sultan Celik; Erkan Yavuz; Atilla Celik; Fatih Celebi

doi:10.3402/fnr.v60.30888

Osman Bilgin Gulcicek istanbul Bagcilar Training And Research Hospital
Kamil Ozdogan istanbul Bagcilar Training And Research Hospital
Ali Solmaz istanbul Bagcilar Training And Research Hospital
Hakan Yigitbas istanbul Bagcilar Training And Research Hospital
Serdar Altınay istanbul Bagcilar Training And Research Hospital
Aysegul Gunes istanbul Bagcilar Training And Research Hospital
Duygu Sultan Celik istanbul Bagcilar Training And Research Hospital
Erkan Yavuz istanbul Bagcilar Training And Research Hospital
Atilla Celik istanbul Bagcilar Training And Research Hospital
Fatih Celebi istanbul Bagcilar Training And Research Hospital

DOI: https://doi.org/10.3402/fnr.v60.30888

Keywords: obesity, sleeve gastrectomy, gastric plication

Abstract

Introduction: Obesity has recently become a major health problem, and researchers have been directed to work toward the development of surgical techniques, with new mediators playing an important role in nutrition. Gastric plication (GP) and sleeve gastrectomy (SG) have become popular recently. These are widely used techniques in bariatric surgery.

Objectives: In this study, we aimed to compare the efficiency of SG and GP techniques on rats.

Methods: Wistar-Hannover rats (n=18) were divided into three equal groups, namely SG, GP, and control. Blood samples were taken before the operation and on the 30th day after the operation. The weights of all rats were recorded both on first day and the 30th day after the operation. Serum gastrin, ghrelin, and leptin levels were also measured on the same days. For histopathological examination, gastrectomy was performed after the animals were sacrificed.

Results: Average weight loss was 10% for the SG group and 6.5% for the GP group. One month after the operations, the decrease in the ghrelin and leptin levels of GP and SG groups was significant compared with the levels of the control group. Gastrin levels of the SG group increased significantly compared with those of the control group. Histopathological examination revealed that there was significant decrease in the ghrelin and leptin levels of the GP and SG groups compared with those of the control group. Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.

Conclusion: Although GP is not as effective as SG in terms of weight loss, it provides the same effectiveness in decreasing ghrelin and leptin levels. Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.

Keywords: obesity; sleeve gastrectomy; gastric plication

(Published: 15 April 2016)

Citation: Food & Nutrition Research 2016, 60: 30888 - http://dx.doi.org/10.3402/fnr.v60.30888