Pantothenic acid – a scoping review for Nordic Nutrition Recommendations 2023

  • Riitta Freese Department of Food and Nutrition, University of Helsinki, Helsinki, Finland
  • Tonje E. Aarsland Innlandet Hospital Trust, Lillehammer, Norway; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
  • Maja Bjørkevoll Innlandet Hospital Trust, Lillehammer, Norway; and Centre for International Health, University of Bergen, Bergen, Norway
Keywords: pantothenic acid, Coenzyme A, requirements, nutrition recommendations, Nordic countries

Abstract

Pantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP). It is widely distributed in animal and plant-source foods. Nutritional deficiency of pantothenic acid is rare and toxicity negligible. Information on pantothenic acid intakes in the Nordic countries is limited and biomarker data from Nordic and Baltic populations is missing. Due to a lack of data, no dietary reference values (DRVs) were given for pantothenic acid in the Nordic Nutrition Recommendations (NNR) since 2012. The aim of this scoping review was to examine recent evidence relevant for updating the DRVs for NNR2023. Scientific literature since 2012 on associations of pantothenic acid with health-related issues in Nordic and Baltic countries was searched. No health concerns related to pantothenic acid were identified.

Downloads

Download data is not yet available.

References


1.
Blomhoff R, Andersen R, Arnesen EK, Christensen JJ, Eneroth H, Erkkola M, et al. Nordic Nutrition Recommendations 2023. Copenhagen: Nordic Council of Ministers; 2023.


2.
Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, Høyer A, et al. The Nordic Nutrition Recommendations 2022 – principles and methodologies. Food Nutr Res 2020; 64: 4402. doi: 10.29219/fnr.v64.4402


3.
Høyer A, Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, et al. The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews. Food Nutr Res 2021; 65: 7828 doi: 10.29219/fnr.v65.7828


4.
Baron JM, Glatz M, Proksch E. Optimal support of wound healing: new insights. Dermatology 2020; 236(6): 593–600. doi: 10.1159/000505291


5.
Hogarth P, Kurian MA, Gregory A, Csányi B, Zagustin T, Kmiec T, et al. Consensus clinical management guideline for pantothenate kinase-associated neurodegeneration (PKAN). Mol Genet Metab 2017 Mar; 120(3): 278–87. doi: 10.1016/j.ymgme.2016.11.004


6.
Kaskow BJ, Proffitt JM, Blangero J, Moses EK, Abraham LJ. Diverse biological activities of the vascular non-inflammatory molecules – the Vanin pantetheinases. Biochem Biophys Res Commun 2012 Jan 13; 417(2): 653–8. doi: 10.1016/j.bbrc.2011.11.099


7.
Naquet P, Pitari G, Duprè S, Galland F. Role of the Vnn1 pantetheinase in tissue tolerance to stress. Biochem Soc Trans 2014 Aug; 42(4): 1094–100. doi: 10.1042/BST20140092


8.
Nitto T, Onodera K. Linkage between coenzyme A metabolism and inflammation: roles of pantetheinase. J Pharmacol Sci 2013 Sep 20; 123(1): 1–8. doi: 10.1254/jphs.13r01cp


9.
Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat 2017 Dec; 28(8): 766–73. doi: 10.1080/09546634.2017.1325310


10.
Jung S, Kim MK, Choi BY. The long-term relationship between dietary pantothenic acid (vitamin B5) intake and C-reactive protein concentration in adults aged 40 years and older. Nutr Metab Cardiovasc Dis 2017 Sep; 27(9): 806–16. doi: 10.1016/j.numecd.2017.05.008


11.
Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T. Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. J Neurochem 2015 Jul; 134(1): 97–112. doi: 10.1111/jnc.13092


12.
Xu J, Patassini S, Begley P, Church S, Waldvogel HJ, Faull RLM, et al. Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer’s disease. Biochem Biophys Res Commun 2020 Jun 30; 527(3): 676–81. doi: 10.1016/j.bbrc.2020.05.015


13.
Naquet P, Kerr EW, Vickers SD, Leonardi R. Regulation of coenzyme A levels by degradation: the ‘ins and outs’. Prog Lipid Res 2020 Apr; 78: 101028. doi: 10.1016/j.plipres.2020.101028


14.
Combs GF, McClung JP. The vitamins: fundamental aspects in nutrition and health. 5th ed. Amsterdam: Elsevier/Academic Press; 2017.


15.
Mock DM, Matthews NI. Biotin and pantothenic acid. In: Stipanuk MH, Caudill MA, eds. Biochemical, physiological, and molecular aspects of human nutrition. 4th ed. Saint Louis, MO: Elsevier; 2019, pp. 659–73.


16.
Miller JW, Rucker RB. Pantothenic acid. In: Marriott BP, Birt DF, Stalling VA, Yates AA, eds. Present knowledge in nutrition: basic nutrition and metabolism. 11th ed. San Diego, CA: Elsevier Science & Technology; 2020, pp. 273–87.


17.
Nordic Council of Ministers. Nordic Nutrition Recommendations 2012: integrating nutrition and physical activity. Nordic Nutrition Recommendations. Report No: 5. Copenhagen: Nordic Council of Ministers; 2014.


18.
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Institute of Medicine (IOM), Food and Nutrition Board. Washington, DC: National Academy Press; 1998, pp. 357–73.


19.
EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). Scientific opinion on dietary reference values for pantothenic acid. EFSA J 2014; 12(2): 3581, 1–25. doi: 10.2903/j.efsa.2014.3581


20.
Scientific Committee on Food. Opinion of the scientific committee on food on the tolerable upper intake level of pantothenic acid. European Commission, Health and Consumer Protection Directorate General. Brussels: Scientific Committee on Food; 2002.


21.
Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 2011; 437(3): 357–72. doi: 10.1042/BJ20110326


22.
Regulation (EC) No 1925/2006 of the European Parliament and of the Council of 20 December 2006 on the addition of vitamins and minerals and of certain other substances to foods. OJ L 404, 30.12.2006, pp. 26–38. Available from: http://data.europa.eu/eli/reg/2006/1925/oj [cited 14 October 2022].


23.
Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002 on the approximation of the laws of the Member States relating to food supplements. OJ L 183, 12.7.2002, p. 51. Available from: http://data.europa.eu/eli/dir/2002/46/2021-03-20 [cited 14 October 2022].


24.
Fry PC, Fox HM, Tao HG. Metabolic response to a pantothenic acid deficient diet in humans. J Nutr Sci Vitaminol (Tokyo) 1976; 22: 339–46. doi: 10.3177/jnsv.22.339


25.
Hodges RE, Ohlson MA, Bean WB. Pantothenic acid deficiency in man. J Clin Invest 1958; 37: 1642–57. doi: 10.1172/JCI103756


26.
Hodges RE, Bean WB, Ohlson MA, Bleiler R. Human pantothenic acid deficiency produced by omega-methyl pantothenic acid. J Clin Invest 1959; 38: 1421–5. doi: 10.1172/JCI103918
Published
2023-12-13
How to Cite
Freese R., Aarsland T. E., & Bjørkevoll M. (2023). Pantothenic acid – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research, 67. https://doi.org/10.29219/fnr.v67.10255
Section
Nordic Nutrition Recommendations