Thiamin (Vitamin B<sub>1</sub>) – A scoping review for Nordic Nutrition Recommendations 2023

Hanna Sara Strandler; Tor A. Strand

doi:10.29219/fnr.v67.10290

Hanna Sara Strandler Swedish Food Agency Uppsala, Sweden
Tor A. Strand Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway

DOI: https://doi.org/10.29219/fnr.v67.10290

Keywords: thiamine, vitamin B1, vitamins, recommendations

Abstract

Only a few studies have explored relationships between thiamine intake and function, and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, makes a useful contribution to understanding requirements in healthy populations. The requirement of thiamine relates to energy and carbohydrate intake. Clinical signs of deficiency have been observed at intakes below 0.5 mg/day, which corresponds to 0.05 mg/MJ. In other studies, thiamine excretion in the urine and normalisation of enzyme activity were normalised at intakes of 0.07–0.08 mg/MJ. The lower limit of intake thus estimates at 0.05 mg/MJ. It has not been possible to set a safe upper intake level for thiamine due to a lack of data.

Studies on pregnant and lactating women indicate a higher requirement as assessed by biochemical parameters. A few studies indicate that thiamine utilisation is impaired among elderly subjects.

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References

1.
EFSA Panel on Dietetic Products, Nurtition and Allergies, Turck D, Bresson J-L, Burlingame B, Dean T, Fairweather-Tait S, et al. Dietary reference values for thiamin. EFSA J 2016; 14(12): e04653. doi: 10.2903/j.efsa.2016.4653

2.
Bettendorff L. Chapter 10. Thiamine In Present Knowledge in Nutrition. Published in London Marriott BP, Birt DF, Stallings VA, Yates AA, editors. 11th ed. London: Academic Press; 2020, p. 171–88.

3.
Lonsdale D. Thiamin. Adv Food Nutr Res 2018; 83: 1–56. doi: 10.1016/bs.afnr.2017.11.001

4.
Sauberlich HE, Herman YF, Stevens CO, Herman RH. Thiamin requirement of the adult human. Am J Clin Nutr 1979; 32(11): 2237–48. doi: 10.1093/ajcn/32.11.2237

5.
McCourt JA, Nixon PF, Duggleby RG. Thiamin nutrition and catalysis-induced instability of thiamin diphosphate. Br J Nutr 2006; 96(4): 636–8.

6.
Ball GFM. Vitamins in foods: analysis, bioavailability, and stability. Boca Raton, FL: CRC Press; 2006.

7.
Bettendorff L. Thiamin. In: Zempleni J, Suttie JW, Gregory III JF, Stover PJ, editors. Handbook of vitamins. 5th ed. Boca Raton, FL: CRC Press; 2014. p. 267-323.

8.
Bender DA. Optimum nutrition: thiamin, biotin and pantothenate. Proc Nutr Soc 1999; 58(2): 427–33. doi: 10.1017/S0029665199000567

9.
Beméur C, Butterworth RF. Thiamin. In: Ross AC, Caballero B, Robert J. C, Tucker KL, Ziegler TR, editors. Modern nutrition in health and disease. Baltimore, MD: Lippincott Williams & Wilkins; 2014. p.317-24.

10.
McCann A, Midttun O, Whitfield KC, Kroeun H, Borath M, Sophonneary P, et al. Comparable performance characteristics of plasma thiamine and erythrocyte thiamine diphosphate in response to thiamine fortification in rural cambodian women. Nutrients 2017; 9(7):676. doi: 10.3390/nu9070676

11.
Whitfield KC, Smith TJ, Rohner F, Wieringa FT, Green TJ. Thiamin fortification strategies in low- and middle-income settings: a review. Ann N Y Acad Sci 2021; 1498(1): 29–45. doi: 10.1111/nyas.14565

12.
Blomhoff R, Andersen R, Arnesen EK, Christensen JJ, Eneroth H, Erkkola M, et al. Nordic Nutrition Recommendations 2023: integrating environmental aspects. Copenhagen: Nordisk Ministerråd; 2023.

13.
Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, Hoyer A, et al. The Nordic Nutrition Recommendations 2022 – principles and methodologies. Food & Nutrition Research 2020; 64: 4402. doi: 10.29219/fnr.v64.4402

14.
Høyer A, Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, et al. The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews. Food & Nutrition Research 2020; 65:7828. doi: 10.29219/fnr.v65.7828

15.
[Thiamin] [database on the Internet]. 2017 [cited 15 July 2022]. Available from: https://www.degruyter.com/database/IUPAC/entry/iupac.compound.1130/html

16.
Information NCfB. PubChem compound summary for CID 1130, Thiamin. 2022 [cited 9 May 2022]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Thiamin

17.
Schenk G, Duggleby RG, Nixon PF. Properties and functions of the thiamin diphosphate dependent enzyme transketolase. Int J Biochem Cell Biol 1998; 30(12): 1297–318. doi: 10.1016/S1357-2725(98)00095-8

18.
Voet D, Voet JG, Pratt CW. Principles of biochemistry. 4th ed. Hoboken, NJ: Wiley, Cop; 2013.

19.
Gangolf M, Czerniecki J, Radermecker M, Detry O, Nisolle M, Jouan C, et al. Thiamin status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One 2010; 5(10): e13616. doi: 10.1371/journal.pone.0013616

20.
Jakobsen J. Optimisation of the determination of thiamin, 2-(1-hydroxyethyl)thiamin, and riboflavin in food samples by use of HPLC. Food Chem 2008; 106(3): 1209–17. doi: 10.1016/j.foodchem.2007.06.008

21.
European Parliament, Council of the European Union. Regulation (EC) No 1925/2006 of the European Parliament and of the Council of 20 December 2006 on the addition of vitamins and minerals and of certain other substances to foods. Official Journal of the European Union L 404, 30 dec, p. 26–38. http://data.europa.eu/eli/reg/2006/1925/oj

22.
Ball GFM. Vitamins: their role in the human body. 2nd ed. Oxford: Blackwell Publishing Ltd; 2004.

23.
Gregory JF, 3rd. Bioavailability of thiamin. Eur J Clin Nutr 1997; 51 Suppl 1: S34–7.

24.
Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 2011; 437(3): 357–72. doi: 10.1042/BJ20110326

25.
Zielinska-Dawidziak M, Grajek K, Olejnik A, Czaczyk K, Grajek W. Transport of high concentration of thiamin, riboflavin and pyridoxine across intestinal epithelial cells Caco-2. J Nutr Sci Vitaminol (Tokyo) 2008; 54(6): 423–9. doi: 10.3177/jnsv.54.423

26.
Smithline HA, Donnino M, Greenblatt DJ. Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects. BMC Clin Pharmacol 2012; 12: 4. doi: 10.1186/1472-6904-12-4

27.
Ariaey-Nejad MR, Balaghi M, Baker EM, Sauberlich HE. Thiamin metabolism in man. Am J Clin Nutr 1970; 23(6): 764–78. doi: 10.1093/ajcn/23.6.764

28.
SCF (Scientific Committee on Food). Opinion of the Scientific Committee on Food on the tolerable upper intake level of vitamin B1. SCF/CS/NUT/UPPLEV/46 Final. Brussels: European Commission; 2001; p. 8. https://food.ec.europa.eu/system/files/2020-12/sci-com_scf_out93_en.pdf

29.
Manzetti S, Zhang J, van der Spoel D. Thiamin function, metabolism, uptake, and transport. Biochemistry 2014; 53(5): 821–35. doi: 10.1021/bi401618y

30.
Finglas PM. Thiamin. Int J Vitam Nutr Res 1993; 63(4): 270–4.

31.
Talwar D, Davidson H, Cooney J, St JRD. Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay. Clin Chem 2000; 46(5): 704–10. doi: 10.1093/clinchem/46.5.704

32.
Tallaksen CM, Bohmer T, Bell H. Blood and serum thiamin and thiamin phosphate esters concentrations in patients with alcohol dependence syndrome before and after thiamin treatment. Alcohol Clin Exp Res 1992; 16(2): 320–5. doi: 10.1111/j.1530-0277.1992.tb01384.x

33.
Bailey AL, Finglas PM, Wright AJ, Southon S. Thiamin intake, erythrocyte transketolase (EC 2.2.1.1) activity and total erythrocyte thiamin in adolescents. Br J Nutr 1994; 72(1): 111–25. doi: 10.1079/BJN19940014

34.
Sriram K, Manzanares W, Joseph K. Thiamin in nutrition therapy. Nutr Clin Pract 2012; 27(1): 41–50. doi: 10.1177/0884533611426149

35.
Akhouri S, Kuhn J, Newton EJ. Wernicke-Korsakoff Syndrome. 2022. [cited 2023 Jun 26]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28613480

36.
Kabat GC, Miller AB, Jain M, Rohan TE. Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer 2008; 99(5): 816–21. doi: 10.1038/sj.bjc.6604540

37.
Key TJ, Appleby PN, Masset G, Brunner EJ, Cade JE, Greenwood DC, et al. Vitamins, minerals, essential fatty acids and colorectal cancer risk in the United Kingdom Dietary Cohort Consortium. Int J Cancer 2012; 131(3): E320–5. doi: 10.1002/ijc.27386

38.
Pelucchi C, Tramacere I, Bertuccio P, Tavani A, Negri E, La Vecchia C. Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study. Ann Oncol 2009; 20(1): 160–5.

39.
Lu’o’ng K, Nguyen LT. Role of thiamine in Alzheimer’s disease. Am J Alzheimers Dis Other Demen 2011; 26(8): 588–98. doi: 10.1177/1533317511432736

40.
Balk E, Chung M, Raman G, Tatsioni A, Chew P, Ip S, et al. B vitamins and berries and age-related neurodegenerative disorders. Evid Rep Technol Assess (Full Rep) 2006; 134: 1–161.

41.
Fessel J. Supplemental thiamine as a practical, potential way to prevent Alzheimer’s disease from commencing. Alzheimers Dement (N Y) 2021; 7(1): e12199. doi: 10.1002/trc2.12199

42.
Koh F, Charlton K, Walton K, McMahon AT. Role of dietary protein and thiamine intakes on cognitive function in healthy older people: a systematic review. Nutrients 2015; 7(4): 2415–39. doi: 10.3390/nu7042415

43.
Strohm D, Bechthold A, Isik N, Leschik-Bonnet E, Heseker H. Revised reference values for the intake of thiamin (vitamin B₁), riboflavin (vitamin B₂), and niacin. NFS J 2016; 3: 20–4. doi: 10.1016/j.nfs.2016.02.003

44.
WHO. Vitamin and mineral requirements in human nutrition. 2nd ed. Geneva: World Health Organization; 2005.

45.
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate OBV, and Choline. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academies Press (US); 1998.

46.
Nordic Council of Ministers. Nordic Nutrition Recommendations 2012: Integrating nutrition and physical activity. 5th ed. Copenhagen, Denmark; 2014.

47.
Nichols HK, Basu TK. Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response. J Am Coll Nutr 1994; 13(1): 57–61. doi: 10.1080/07315724.1994.10718372

Thiamin (Vitamin B1) – A scoping review for Nordic Nutrition Recommendations 2023

Abstract

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Thiamin (Vitamin B₁) – A scoping review for Nordic Nutrition Recommendations 2023