Selenium – a scoping review for Nordic Nutrition Recommendations 2023

  • Jan Alexander Norwegian Institute of Public Health, Oslo, Norway
  • Ann-Karin Olsen Norwegian Institute of Public Health, Oslo, Norway
DOI: https://doi.org/10.29219/fnr.v67.10320
Keywords: selenium, selenoprotein, trace elements, antioxidants, nutrition recommendations

Abstract

Selenium is an essential trace element in humans, critical to the normal physiology in all animal species. The main form of selenium in food is selenomethionine, selenocysteine and a variety of organic compounds, while inorganic salts mainly occur in food supplements. In animals and humans, selenium occurs as selenocysteine in selenoproteins encoded by 25 genes (specific selenium pool). Several selenoproteins are part of the antioxidant enzyme system and serve as oxido-reductases and in thyroid hormone regulation. SelenoproteinP (SELENOP) transports selenium to peripheral tissues, is the main plasma selenoprotein, and has been used as biomarker of selenium status and intake. SELENOP in plasma represents a saturable pool of selenium and is maximised at a selenium concentration in plasma of about 110 µg/L or an intake of selenomethionine at about 1.2 µg/kg body weight in adults. In Finland, with an estimated selenium intake of 88 µg/day in men and 68 µg/day in women, the average selenium concentration in plasma is about 110 µg/L. Imported wheat from selenium rich areas is an important dietary source in Norway. Dietary intakes in the Nordic and Baltic area vary from 39 to 88 µg/day in men and 22 to 68 µg/day in women, the highest levels were from Finland. Most intervention trials on the effect of selenium supplementation on health outcomes have been carried out in ‘selenium-replete’-populations and show no beneficial effect, which from a nutritional point of view would rather not be expected. Some intervention studies conducted in populations low in selenium have showed a beneficial effect. Observational studies suggest an inverse relationship between selenium status and risk of cardiovascular diseases (CVDs), cancer and all-cause mortality, and some other outcomes at low levels of intake (<55 µg/day) or in plasma or serum (<100 µg/L). However, a lack of quantitative data and inconsistencies between studies precludes these studies to be used to derive dietary reference values. At high intakes above 330 to 450 µg/day selenium may cause toxic effects affecting liver, peripheral nerves, skin, nails, and hair. An upper tolerable level (UL) of 255 µg selenium/day in adults was established by EFSA.

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References


1.
Alexander J. Selenium. In: Nordberg GF, Costa M, editors. Handbook on the toxicology of metals. 2. Washington, DC: Academic Press; 2022, pp. 730–71.


2.
Rayman MP. Food-chain selenium and human health: emphasis on intake. Br J Nutr 2008; 100(2):254–68. doi: 10.1017/S0007114508939830


3.
Rayman MP. Selenium intake, status, and health: a complex relationship. Hormones 2020; 19(1): 9–14. doi: 10.1007/s42000-019-00125-5


4.
EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA). Scientific opinion on dietary reference values for selenium. EFSA J 2014; 12(10): 67. doi: 10.2903/j.efsa.2014.3846


5.
Nordic Council of Ministers. Nordic Nutrition Recommendations 2012 – integrating nutrition and physical activity. Copenhagen: Nordic Council of Ministers; 2014.


6.
Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, Hoyer A, et al. The Nordic Nutrition Recommendations 2022 – principles and methodologies. Food Nutr Res 2020; 64: 1–15. doi: 10.29219/fnr.v64.4402


7.
Blomhoff R, Andersen R, Arnesen EK, Christensen JJ, Eneroth H, Erkkola M, et al. Nordic Nutrition Recommendations 2023. Copenhagen: Nordic Council of Ministers; 2023.


8.
Høyer A, Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, et al. The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews. Food Nutr Res 2021; 65: 1–38. doi: 10.29219/fnr.v65.7828


9.
Burk RF, Hill KE. Regulation of selenium metabolism and transport. Annu Rev Nutr 2015; 35: 109–34. doi: 10.1146/annurev-nutr-071714-034250


10.
Rayman MP. Selenium and human health. Lancet 2012; 379(9822): 1256–68. doi: 10.1016/S0140-6736(11)61452-9


11.
Hadrup N, Ravn-Haren G. Absorption, distribution, metabolism and excretion (ADME) of oral selenium from organic and inorganic sources: a review. J Trace Elem Med Biol 2021; 67: 126801. doi: 10.1016/j.jtemb.2021.126801


12.
Mutanen M. Bioavailability of selenium. Ann Clin Res 1986; 18(1): 48–54.


13.
Fox TE, Van den Heuvel EG, Atherton CA, Dainty JR, Lewis DJ, Langford NJ, et al. Bioavailability of selenium from fish, yeast and selenate: a comparative study in humans using stable isotopes. Eur J Clin Nutr 2004; 58(2): 343–9. doi: 10.1038/sj.ejcn.1601787


14.
Thorngren M, Akesson B. Effect of dietary fish on plasma selenium and its relation to haemostatic changes in healthy adults. Int J Vitam Nutr Res 1987; 57(4): 429–35.


15.
Meltzer HM, Bibow K, Paulsen IT, Mundal HH, Norheim G, Holm H. Different bioavailability in humans of wheat and fish selenium as measured by blood-platelet response to increased dietary Se. Biol Trace Elem Res 1993; 36(3): 229–41. doi: 10.1007/Bf02783957


16.
Arias-Borrego A, Callejon-Leblic B, Rodriguez-Moro G, Velasco I, Gomez-Ariza JL, Garcia-Barrera T. A novel HPLC column switching method coupled to ICP-MS/QTOF for the first determination of selenoprotein P (SELENOP) in human breast milk. Food Chem 2020; 321: 126692. doi: 10.1016/j.foodchem.2020.126692


17.
Hurst R, Collings R, Harvey LJ, King M, Hooper L, Bouwman J, et al. EURRECA-Estimating selenium requirements for deriving dietary reference values. Crit Rev Food Sci Nutr 2013; 53(10): 1077–96. doi: 10.1080/10408398.2012.742861


18.
Marciel MP, Hoffmann PR. Molecular mechanisms by which selenoprotein K regulates immunity and cancer. Biol Trace Elem Res 2019; 192(1): 60–8. doi: 10.1007/s12011-019-01774-8


19.
Levander OA, Alfthan G, Arvilommi H, Gref CG, Huttunen JK, Kataja M, et al. Bioavailability of selenium to Finnish men as assessed by platelet glutathione peroxidase activity and other blood parameters. Am J Clin Nutr 1983; 37(6): 887–97. doi: 10.1093/ajcn/37.6.887


20.
Thomson CD, Robinson MF, Butler JA, Whanger PD. Long-term supplementation with selenate and selenomethionine: selenium and glutathione peroxidase (EC 1.11.1.9) in blood components of New Zealand women. Br J Nutr 1993; 69(2): 577–88. doi: 10.1079/bjn19930057


21.
Thomson CD, Robinson MF, Campbell DR, Rea HM. Effect of prolonged supplementation with daily supplements of selenomethionine and sodium selenite on glutathione peroxidase activity in blood of New Zealand residents. Am J Clin Nutr 1982; 36(1): 24–31. doi: 10.1093/ajcn/36.1.24


22.
Thomson CD, Steven SM, van Rij AM, Wade CR, Robinson MF. Selenium and vitamin E supplementation: activities of glutathione peroxidase in human tissues. Am J Clin Nutr 1988; 48(2): 316–23. doi: 10.1093/ajcn/48.2.316


23.
Alfthan G, Aro A, Arvilommi H, Huttunen JK. Selenium metabolism and platelet glutathione peroxidase activity in healthy Finnish men: effects of selenium yeast, selenite, and selenate. Am J Clin Nutr 1991; 53(1): 120–5. doi: 10.1093/ajcn/53.1.120


24.
Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, et al. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Am J Clin Nutr 2010; 92(3): 525–31. doi: 10.3945/ajcn.2010.29642


25.
Duffield AJ, Thomson CD, Hill KE, Williams S. An estimation of selenium requirements for New Zealanders. Am J Clin Nutr 1999; 70(5): 896–903. doi: 10.1093/ajcn/70.5.896


26.
Neve J. Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity. J Trace Elem Med Biol 1995; 9(2): 65–73. doi: 10.1016/S0946-672X(11)80013-1


27.
Thomson CD. Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr 2004; 58(3): 391–402. doi: 10.1038/sj.ejcn.1601800


28.
Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 2006; 15(4): 804–10. doi: 10.1158/1055-9965.EPI-05-0950


29.
Hurst R, Armah CN, Dainty JR, Hart DJ, Teucher B, Goldson AJ, et al. Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2010; 91(4): 923–31. doi: 10.3945/ajcn.2009.28169


30.
EFSA NDA Panel (EFSA Panel on Dietetic Products NaA. Scientific Opinion on Dietary Reference Values for Selenium. EFSA J 2014; 12(10): 67. doi: 10.2903/j.efsa.2014.3846


31.
Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, et al. High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal 2012; 16(3): 185–92. doi: 10.1089/ars.2011.3997


32.
Marshall JR, Burk RF, Payne Ondracek R, Hill KE, Perloff M, Davis W, et al. Selenomethionine and methyl selenocysteine: multiple-dose pharmacokinetics in selenium-replete men. Oncotarget 2017; 8(16): 26312–22. doi: 10.18632/oncotarget.15460


33.
Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr. 2005; 81(4): 829–34. doi: 10.1093/ajcn/81.4.829


34.
Ballihaut G, Kilpatrick LE, Davis WC. Detection, identification, and quantification of selenoproteins in a candidate human plasma standard reference material. Anal Chem 2011; 83(22): 8667–74. doi: 10.1021/ac2021147


35.
Ballihaut G, Kilpatrick LE, Kilpatrick EL, Davis WC. Multiple forms of selenoprotein P in a candidate human plasma standard reference material. Metallomics 2012; 4(6): 533–8. doi: 10.1039/c2mt20059g


36.
Johnson CC, Fordyce FM, Rayman MP. Symposium on ‘Geographical and geological influences on nutrition’: factors controlling the distribution of selenium in the environment and their impact on health and nutrition. Proc Nutr Soc 2010; 69(1): 119–32. doi: 10.1017/S0029665109991807


37.
Alfthan G, Eurola M, Ekholm P, Venalainen ER, Root T, Korkalainen K, et al. Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: from deficiency to optimal selenium status of the population. J Trace Elem Med Biol 2015; 31: 142–7. doi: 10.1016/j.jtemb.2014.04.009


38.
Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, et al. Selenium in human health and disease. Antioxid Redox Signal 2011; 14(7): 1337–83. doi: 10.1089/ars.2010.3275


39.
Ellingsen DG, Thomassen Y, Rustad P, Molander P, Aaseth J. The time-trend and the relation between smoking and circulating selenium concentrations in Norway. J Trace Elem Med Biol 2009; 23(2): 107–15. doi: 10.1016/j.jtemb.2009.01.004


40.
Nordic-Council-of-Ministers. Nordic Nutrition Recommendations 2012: integrating nutrition and physical activity. Copenhagen: Nordic Council of Ministers; 2014. Contract No.: Report No: 5.


41.
Kristensen NB, Madsen ML, Hansen TH, Allin KH, Hoppe C, Fagt S, et al. Intake of macro- and micronutrients in Danish vegans. Nutr J 2015; 14: 115. doi: 10.1186/s12937-015-0103-3


42.
Larsson CL, Johansson GK. Dietary intake and nutritional status of young vegans and omnivores in Sweden. Am J Clin Nutr 2002; 76(1): 100–6. doi: 10.1093/ajcn/76.1.100


43.
Elorinne AL, Alfthan G, Erlund I, Kivimaki H, Paju A, Salminen I, et al. Food and nutrient intake and nutritional status of finnish vegans and non-vegetarians. PLoS One 2016; 11(2): e0148235. doi: 10.1371/journal.pone.0148235


44.
Lemming EW, Pitsi T. The Nordic Nutrition Recommendations 2022 – food consumption and nutrient intake in the adult population of the Nordic and Baltic countries. Food Nutr Res 2022; 66: 1–10. doi: 10.29219/fnr.v66.8572


45.
Hustad KS, Ottestad I, Olsen T, Saether T, Ulven SM, Holven KB. Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial. Eur J Nutr 2022; 61(6): 3085–93. doi: 10.1007/s00394-022-02857-4


46.
Helland A, Bratlie M, Hagen IV, Midttun O, Sveier H, Mellgren G, et al. Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial. Eur J Nutr 2021; 60(6): 3237–48. doi: 10.1007/s00394-021-02497-0


47.
Oyen J, Aadland EK, Liaset B, Fjaere E, Dahl L, Madsen L. Lean-seafood intake increases urinary iodine concentrations and plasma selenium levels: a randomized controlled trial with crossover design. Eur J Nutr 2021; 60(3): 1679–89. doi: 10.1007/s00394-020-02366-2


48.
Molin M, Ulven SM, Dahl L, Lundebye AK, Holck M, Alexander J, et al. Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers – a randomized controlled trial. J Trace Elem Med Biol 2017; 44: 1–7. doi: 10.1016/j.jtemb.2017.05.004


49.
Gustin K, Barman M, Skroder H, Jacobsson B, Sandin A, Sandberg AS, et al. Thyroid hormones in relation to toxic metal exposure in pregnancy, and potential interactions with iodine and selenium. Environ Int 2021; 157: 106869. doi: 10.1016/j.envint.2021.106869


50.
Alehagen U, Alexander J, Aaseth J. Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. A secondary analysis of a randomised clinical trial. PLoS One 2016; 11(7): e0157541. doi: 10.1371/journal.pone.0157541


51.
Rayman MP, Winther KH, Pastor-Barriuso R, Cold F, Thvilum M, Stranges S, et al. Effect of long-term selenium supplementation on mortality: results from a multiple-dose, randomised controlled trial. Free Radic Biol Med 2018; 127: 46–54. doi: 10.1016/j.freeradbiomed.2018.02.015


52.
Outzen M, Tjonneland A, Larsen EH, Andersen KK, Christensen J, Overvad K, et al. The effect on selenium concentrations of a randomized intervention with fish and mussels in a population with relatively low habitual dietary selenium intake. Nutrients 2015; 7(1): 608–24. doi: 10.3390/nu7010608


53.
Long M, Knudsen AK, Pedersen HS, Bonefeld-Jorgensen EC. Food intake and serum persistent organic pollutants in the Greenlandic pregnant women: the ACCEPT sub-study. Sci Total Environ 2015; 529: 198–212. doi: 10.1016/j.scitotenv.2015.05.022


54.
Skesters A, Kustovs D, Lece A, Moreino E, Petrosina E, Rainsford KD. Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery. Inflammopharmacology 2022; 30(2): 499–503. doi: 10.1007/s10787-022-00925-z


55.
Zake T, Kalere I, Upmale-Engela S, Svirskis S, Gersone G, Skesters A, et al. Plasma levels of Th17-associated cytokines and selenium status in autoimmune thyroid diseases. Immun Inflamm Dis 2021; 9(3): 792–803. doi: 10.1002/iid3.433


56.
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. Chin Med J 1979; 92(7): 477–82.


57.
Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J 1979; 92(7): 471–6.


58.
Beck MA, Levander OA. Host nutritional status and its effect on a viral pathogen. J Infect Dis 2000; 182 Suppl 1: S93–6. doi: 10.1086/315918


59.
Shahmiri SS, Eghbali F, Ismaeil A, Gholizadeh B, Khalooeifard R, Valizadeh R, et al. Selenium deficiency after bariatric surgery, incidence and symptoms: a systematic review and meta-analysis. Obes Surg 2022; 32(5): 1719–25. doi: 10.1007/s11695-022-05932-1


60.
Boldery R, Fielding G, Rafter T, Pascoe AL, Scalia GM. Nutritional deficiency of selenium secondary to weight loss (bariatric) surgery associated with life-threatening cardiomyopathy. Heart Lung Circ 2007; 16(2): 123–6. doi: 10.1016/j.hlc.2006.07.013


61.
Johnson RA, Baker SS, Fallon JT, Maynard EP, 3rd, Ruskin JN, Wen Z, et al. An occidental case of cardiomyopathy and selenium deficiency. N Engl J Med 1981; 304(20): 1210–2. doi: 10.1056/NEJM198105143042005


62.
Al-Matary A, Hussain M, Ali J. Selenium: a brief review and a case report of selenium responsive cardiomyopathy. BMC Pediatr 2013; 13: 39. doi: 10.1186/1471-2431-13-39


63.
Lv Y, Yu T, Yang Z, Zhao W, Zhang M, Wang Q. Constraint on selenium bioavailability caused by its geochemical behavior in typical Kaschin-Beck disease areas in Aba, Sichuan Province of China. Sci Total Environ 2014; 493: 737–49. doi: 10.1016/j.scitotenv.2014.06.050


64.
Zhao ZJ, Li Q, Yang PZ, Wang H, Kong LC, Wang LH, et al. Selenium: a protective factor for Kaschin-Beck disease in Qing-Tibet Plateau. Biol Trace Elem Res 2013; 153(1–3): 1–4. doi: 10.1007/s12011-013-9686-8


65.
Sun LY, Li Q, Meng FG, Fu Y, Zhao ZJ, Wang LH. T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province. Biol Trace Elem Res 2012; 150(1–3): 371–5. doi: 10.1007/s12011-012-9469-7


66.
Peng A, Wang WH, Wang CX, Wang ZJ, Rui HF, Wang WZ, et al. The role of humic substances in drinking water in Kashin-Beck disease in China. Environ Health Perspect 1999; 107(4): 293–6. doi: 10.1289/ehp.99107293


67.
Vanderpas JB, Contempre B, Duale NL, Goossens W, Bebe N, Thorpe R, et al. Iodine and selenium deficiency associated with cretinism in northern Zaire. Am J Clin Nutr 1990; 52(6): 1087–93. doi: 10.1093/ajcn/52.6.1087


68.
Pedersen AN FS, Velsing Groth M. Danskernes kostvaner 2003–2008. Hovedresultater (Dietary habits of Danes 2003–2008. Main results). Copenhagen: DTU Fødevareinstitutet; 2010.


69.
Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009; 301(1): 39–51. doi: 10.1001/jama.2008.864


70.
SCF. Opinion of the Scientific Committee on Food on the tolerable upper intake level of selenium. SCF/CS/NUT/UPPLEV/25 Final. Brussel: European Commission, Health and Consumer Protection Directorate General. Scientific Committee on Food; 2000.


71.
EFSA NDA Panel (EFSA Panel on Nutrition NFaFA. Scientific opinion on the tolerable upper intake level for selenium. EFSA J 2023; 21(1): 194. doi: 10.2903/j.efsa.2023.7704


72.
Salonen JT, Alfthan G, Huttunen JK, Pikkarainen J, Puska P. Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. Lancet 1982; 2(8291): 175–9. doi: 10.1016/s0140-6736(82)91028-5


73.
Suadicani P, Hein HO, Gyntelberg F. Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males. Atherosclerosis 1992; 96(1): 33–42. doi: 10.1016/0021-9150(92)90035-f


74.
Rees K, Hartley L, Day C, Clarke A, Stranges S. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2012; 2012(2). doi: 10.1002/14651858.CD009671


75.
Stranges S, Marshall JR, Trevisan M, Natarajan R, Donahue RP, Combs GF, et al. Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial. Am J Epidemiol 2006; 163(8): 694–9. doi: 10.1093/aje/kwj097


76.
Zhang X, Liu C, Guo J, Song Y. Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. Eur J Clin Nutr 2016; 70(2): 162–9. doi: 10.1038/ejcn.2015.78


77.
Jenkins DJA, Kitts D, Giovannucci EL, Sahye-Pudaruth S, Paquette M, Blanco Mejia S, et al. Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2020; 112(6): 1642–52. doi: 10.1093/ajcn/nqaa245


78.
Kuria A, Tian H, Li M, Wang Y, Aaseth JO, Zang J, et al. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis. Crit Rev Food Sci Nutr 2021; 61(21): 3616–25. doi: 10.1080/10408398.2020.1803200


79.
Alehagen U, Aaseth J, Alexander J, Johansson P. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: a validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS One 2018; 13(4): e0193120. doi: 10.1371/journal.pone.0193120


80.
Mueller AS, Pallauf J. Compendium of the antidiabetic effects of supranutritional selenate doses. In vivo and in vitro investigations with type II diabetic db/db mice. J Nutr Biochem 2006; 17(8): 548–60. doi: 10.1016/j.jnutbio.2005.10.006


81.
McNeill JH, Delgatty HL, Battell ML. Insulinlike effects of sodium selenate in streptozocin-induced diabetic rats. Diabetes 1991; 40(12): 1675–8. doi: 10.2337/diab.40.12.1675


82.
Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147(4): 217–23. doi: 10.7326/0003-4819-147-4-200708210-00175


83.
Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, et al. Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes. J Natl Cancer Inst 2016; 108(12): 1–10. doi: 10.1093/jnci/djw152


84.
Kohler LN, Foote J, Kelley CP, Florea A, Shelly C, Chow H-HS, Hsu P, Batai K, Ellis N, Saboda K, et al. Selenium and Type 2 Diabetes: Systematic Review. Nutrients. 2018; 10(12):1924. doi: 10.3390/nu10121924


85.
Kohler LN, Florea A, Kelley CP, Chow S, Hsu P, Batai K, et al. Higher plasma selenium concentrations are associated with increased odds of prevalent type 2 diabetes. J Nutr 2018; 148(8): 1333–40. doi: 10.1093/jn/nxy099


86.
Rayman MP, Stranges S. Epidemiology of selenium and type 2 diabetes: can we make sense of it? Free Radic Biol Med 2013; 65: 1557–64. doi: 10.1016/j.freeradbiomed.2013.04.003


87.
Vinceti M, Filippini T, Wise LA, Rothman KJ. A systematic review and dose-response meta-analysis of exposure to environmental selenium and the risk of type 2 diabetes in nonexperimental studies. Environ Res 2021; 197: 111210. doi: 10.1016/j.envres.2021.111210


88.
Steinbrenner H, Duntas LH, Rayman MP. The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities. Redox Biol 2022; 50: 102236. doi: 10.1016/j.redox.2022.102236


89.
Mao J, Teng W. The relationship between selenoprotein P and glucose metabolism in experimental studies. Nutrients 2013; 5(6): 1937–48. doi: 10.3390/nu5061937


90.
Strozyk A, Osica Z, Przybylak JD, Kolodziej M, Zalewski BM, Mrozikiewicz-Rakowska B, et al. Effectiveness and safety of selenium supplementation for type 2 diabetes mellitus in adults: a systematic review of randomised controlled trials. J Hum Nutr Diet 2019; 32(5): 635–45. doi: 10.1111/jhn.12670


91.
Cai X, Wang C, Yu W, Fan W, Wang S, Shen N, et al. Selenium exposure and cancer risk: an updated meta-analysis and meta-regression. Sci Rep 2016; 6: 19213. doi: 10.1038/srep19213


92.
Kuria A, Fang X, Li M, Han H, He J, Aaseth JO, et al. Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies. Crit Rev Food Sci Nutr 2020; 60(4): 684–94. doi: 10.1080/10408398.2018.1548427


93.
Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, et al. Selenium for preventing cancer. Cochrane Database Syst Rev 2018; 1: CD005195. doi: 10.1002/14651858.CD005195.pub4


94.
Clark LC, Combs GF, Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 1996; 276(24): 1957–63. doi: 10.1001/jama.276.24.1957


95.
Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs GF, Jr, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003; 95(19): 1477–81. doi: 10.1093/jnci/djg061


96.
Lippman SM, Goodman PJ, Klein EA, Parnes HL, Thompson IM, Jr, Kristal AR, et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst 2005; 97(2): 94–102. doi: 10.1093/jnci/dji009


97.
Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, et al. Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. J Natl Cancer Inst 2014; 106(3): djt456. doi: 10.1093/jnci/djt456


98.
Vinceti M, Vicentini M, Wise LA, Sacchettini C, Malagoli C, Ballotari P, et al. Cancer incidence following long-term consumption of drinking water with high inorganic selenium content. Sci Total Environ 2018; 635: 390–6. doi: 10.1016/j.scitotenv.2018.04.097


99.
Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch Intern Med 2008; 168(4): 404–10. doi: 10.1001/archinternmed.2007.74


100.
Akbaraly NT, Arnaud J, Hininger-Favier I, Gourlet V, Roussel AM, Berr C. Selenium and mortality in the elderly: results from the EVA study. Clin Chem 2005; 51(11): 2117–23. doi: 10.1373/clinchem.2005.055301


101.
Ray AL, Semba RD, Walston J, Ferrucci L, Cappola AR, Ricks MO, et al. Low serum selenium and total carotenoids predict mortality among older women living in the community: the women’s health and aging studies. J Nutr 2006; 136(1): 172–6. doi: 10.1093/jn/136.1.172


102.
Wei WQ, Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Sun XD, et al. Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. Am J Clin Nutr 2004; 79(1): 80–5. doi: 10.1093/ajcn/79.1.80


103.
Qiao YL, Dawsey SM, Kamangar F, Fan JH, Abnet CC, Sun XD, et al. Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst 2009; 101(7): 507–18. doi: 10.1093/jnci/djp037


104.
Wang SM, Taylor PR, Fan JH, Pfeiffer RM, Gail MH, Liang H, et al. Effects of nutrition intervention on total and cancer mortality: 25-year post-trial follow-up of the 5.25-year linxian nutrition intervention trial. J Natl Cancer Inst 2018; 110(11): 1229–38. doi: 10.1093/jnci/djy043


105.
Fairweather-Tait SJ, Filippini T, Vinceti M. Selenium status and immunity. Proc Nutr Soc 2022; 82: 1–7. doi: 10.1017/S0029665122002658


106.
Varsi K, Bolann B, Torsvik I, Rosvold Eik TC, Høl PJ, Bjørke-Monsen A-L. Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life. Nutrients. 2017; 9(5):486. doi: 10.3390/nu9050486


107.
Modzelewska D, Solé-Navais P, Brantsæter AL, Flatley C, Elfvin A, Meltzer HM, Sengpiel V, Barman M, Jacobsson B. Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study. Nutrients. 2021; 13(4):1239. doi: 10.3390/nu13041239


108.
Solé-Navais P, Brantsæter AL, Caspersen IH, Lundh T, Muglia LJ, Meltzer HM, Zhang G, Jacobsson B, Sengpiel V, Barman M. Maternal Dietary Selenium Intake during Pregnancy Is Associated with Higher Birth Weight and Lower Risk of Small for Gestational Age Births in the Norwegian Mother, Father and Child Cohort Study. Nutrients. 2021; 13(1):23. doi: 10.3390/nu13010023


109.
Yu R, Wang Z, Ma M, Xu P, Liu L, Tinkov AA, Lei XG, Zhou J-C. Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis. Antioxidants. 2022; 11(7):1263. doi: 10.3390/antiox11071263


110.
Hamdan HZ, Hamdan SZ, Adam I. Association of selenium levels with preeclampsia: a systematic review and meta-analysis. Biol Trace Elem Res 2022; 201: 2105–22. doi: 10.1007/s12011-022-03316-1


111.
Holmquist E, Brantsaeter AL, Meltzer HM, Jacobsson B, Barman M, Sengpiel V. Maternal selenium intake and selenium status during pregnancy in relation to preeclampsia and pregnancy-induced hypertension in a large Norwegian Pregnancy Cohort Study. Sci Total Environ 2021; 798: 149271. doi: 10.1016/j.scitotenv.2021.149271


112.
Barman M, Brantsaeter AL, Nilsson S, Haugen M, Lundh T, Combs GF, et al. Maternal dietary selenium intake is associated with increased gestational length and decreased risk of preterm delivery. Br J Nutr 2020; 123(2): 209–19. doi: 10.1017/S0007114519002113


113.
Kipp AP, Strohm D, Brigelius-Flohe R, Schomburg L, Bechthold A, Leschik-Bonnet E, et al. Revised reference values for selenium intake. J Trace Elem Med Biol 2015; 32: 195–9. doi: 10.1016/j.jtemb.2015.07.005


114.
Swanson CA, Reamer DC, Veillon C, King JC, Levander OA. Quantitative and qualitative aspects of selenium utilization in pregnant and nonpregnant women: an application of stable isotope methodology. Am J Clin Nutr 1983; 38(2): 169–80. doi: 10.1093/ajcn/38.2.169


115.
Thomson CD, Packer MA, Butler JA, Duffield AJ, O’Donaghue KL, Whanger PD. Urinary selenium and iodine during pregnancy and lactation. J Trace Elem Med Biol 2001; 14(4): 210–7. doi: 10.1016/S0946-672X(01)80004-3


116.
Han F, Liu Y, Pang X, Wang Q, Liu L, Chai Y, et al. Low selenium intake is associated with postpartum weight retention in Chinese women and impaired physical development of their offspring. Br J Nutr 2021; 126(10): 1498–509. doi: 10.1017/S0007114521000015


117.
Sabatier M, Garcia-Rodenas CL, De Castro CA, Kastenmayer P, Vigo M, Dubascoux S, Andrey D, Nicolas M, Richoz Payot J, Bordier V, et al. Longitudinal Changes of Mineral Concentrations in Preterm and Term Human Milk from Lactating Swiss Women. Nutrients. 2019; 11(8):1855. doi: 10.3390/nu11081855
Published
2023-12-28
How to Cite
Alexander J., & Olsen A.-K. (2023). Selenium – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research, 67. https://doi.org/10.29219/fnr.v67.10320
Issue
Vol 67 (2023)
Section
Nordic Nutrition Recommendations
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