<em>Curcuma longa</em> L. extract exhibits anti-inflammatory and cytoprotective functions in the articular cartilage of monoiodoacetate-injected rats

Hyelim  Kim; Jaeeun  Jung; Minhee  Lee; Minha  Kim; Namgil  Kang; Ok-Kyung Kim; Jeongmin  Lee

doi:10.29219/fnr.v68.10402

Hyelim Kim Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea
Jaeeun Jung Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea
Minhee Lee Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea; Department of Food Innovation and Health, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea
Minha Kim Nutrione Co., Ltd, Seoul 05510, Republic of Korea
Namgil Kang Nutrione Co., Ltd, Seoul 05510, Republic of Korea
Ok-Kyung Kim Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, 61186, Republic of Korea
Jeongmin Lee Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea; Department of Food Innovation and Health, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea

DOI: https://doi.org/10.29219/fnr.v68.10402

Keywords: osteoarthritis, Curcuma longa L, MMPs, chondrocytes

Abstract

Background: Osteoarthritis (OA), the most prevalent form of arthritis, is a degenerative joint disease marked by the progressive deterioration of articular cartilage, leading to clinical manifestations such as joint pain.

Objective: This study investigated the effects of Curcuma longa L. extract (CL) containing curcumin, demethoxycurcumin, and bisdemethoxycurcumin on monosodium iodoacetate (MIA)-induced OA rats.

Design: Sprague–Dawley rats with MIA-induced OA received CL supplementation at doses of 5, 25, and 40 mg/kg body weight.

Results: CL extract administration suppressed mineralisation parameters and morphological modifications and decreased arachidonate5-lipoxygenase and leukotriene B4 levels in articular cartilage. Additionally, it decreased serum prostaglandin E2, NO, and glycosaminoglycanlevels as well as the protein expression of phosphorylated inhibitor kappa B-alpha, phosphorylated p65, cyclooxygenase-2, and inducible nitric oxide synthase in the cartilage of MIA-injected rats. Furthermore, it also reduced matrix metalloproteinases and elevated SMAD family member 3 phosphorylation, tissue inhibitor of metalloproteinases, aggrecan, collagen type I, and collagen type II levels in the articular cartilage of MIA-induced OA rats.

Conclusions: This study’s findings suggest that CL supplementation helps prevent OA development and is an effective therapy for OA.

Downloads

Download data is not yet available.

References

1.
Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol 2016; 12(7): 412–20. doi: 10.1038/nrrheum.2016.65

2.
Mobasheri A. Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis. Med Hypotheses 2002; 58(3): 193–7. doi: 10.1054/mehy.2000.1180

3.
Goldring MB, Goldring SR. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci 2010; 1192: 230–7. doi: 10.1111/j.1749-6632.2009.05240.x

4.
Hashimoto M, Nakasa T, Hikata T, Asahara H. Molecular network of cartilage homeostasis and osteoarthritis. Med Res Rev 2008; 28(3): 464–81. doi: 10.1002/med.20113

5.
Beaupré GS, Stevens SS, Carter DR. Mechanobiology in the development, maintenance, and degeneration of articular cartilage. J Rehabil Res Dev 2000; 37(2): 145–51.

6.
Huber M, Trattnig S, Lintner F. Anatomy, biochemistry, and physiology of articular cartilage. Invest Radiol 2000; 35(10): 573–80. doi: 10.1097/00004424-200010000-00003

7.
Caterson B, Flannery CR, Hughes CE, Little CB. Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biol 2000; 19(4): 333–44. doi: 10.1016/S0945-053X(00)00078-0

8.
Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, et al. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest 1997; 100(1): 93–106. doi: 10.1172/JCI119526

9.
Taty Anna K, Elvy Suhana MR, Das S, Faizah O, Hamzaini AH. Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: an anatomico-radiological study. Clin Ter 2011; 162(3): 201–7.

10.
Murugan S, Bethapudi B, Purusothaman D, Chandrasekaran PR, Velusami CC. Antiarthritic effect of polar extract of Curcuma longa on monosodium iodoacetate induced osteoarthritis in rats. Antiinflamm Antiallergy Agents Med Chem 2017; 16(3): 193–202. doi: 10.2174/1871523017666180126150341

11.
Kahkhaie KR, Mirhosseini A, Aliabadi A, Mohammadi A, Mousavi MJ, Haftcheshmeh SM, et al. Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology 2019; 27(5): 885–900. doi: 10.1007/s10787-019-00607-3

12.
He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules 2015; 20(5): 9183–213. doi: 10.3390/molecules20059183

13.
Guan VX, Mobasheri A, Probst YC. A systematic review of osteoarthritis prevention and management with dietary phytochemicals from foods. Maturitas 2019; 122: 35–43. doi: 10.1016/j.maturitas.2019.01.005

14.
Pitcher T, Sousa-Valente J, Malcangio M. The monoiodoacetate model of osteoarthritis pain in the mouse. J Vis Exp 2016; 111: 53746. doi: 10.3791/53746-v

15.
Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, et al. Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids. Arthritis Rheum 2004; 50(12): 3925–33. doi: 10.1002/art.20632

16.
Paredes Y, Massicotte F, Pelletier JP, Martel-Pelletier J, Laufer S, Lajeunesse D. Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition. Arthritis Rheum 2002; 46(7): 1804–12. doi: 10.1002/art.10357

17.
Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta 2012; 1824: 133–45. doi: 10.1016/j.bbapap.2011.06.020

18.
Luo Y, Sinkeviciute D, He Y, Karsdal M, Henrotin Y, Mobasheri A, et al. The minor collagens in articular cartilage. Protein Cell 2017; 8(8): 560–72. doi: 10.1007/s13238-017-0377-7

19.
Klatt AR, Paul-Klausch B, Klinger G, Kühn G, Renno JH, Banerjee M, et al. A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes. J Orthop Res 2009; 27(1): 65–70. doi: 10.1002/jor.20716

20.
Cui N, Hu M, Khalil RA. Biochemical and biological attributes of matrix metalloproteinases. Prog Mol Biol Transl Sci 2017; 147: 1–73. doi: 10.1016/bs.pmbts.2017.02.005

21.
Akkiraju H, Nohe A. Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration. J Dev Biol 2015; 3(4): 177–92. doi: 10.3390/jdb3040177

22.
Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther 2020; 20(1): 225. doi: 10.1186/s12906-020-02985-6

23.
Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res 2009; 58(12): 899–908. doi: 10.1007/s00011-009-0063-1

24.
Li X, Feng K, Li J, Yu D, Fan Q, Tang T, et al. Curcumin inhibits apoptosis of chondrocytes through activation ERK1/2 signaling pathways induced autophagy. Nutrients 2017; 9(4): 414. doi: 10.3390/nu9040414

Curcuma longa L. extract exhibits anti-inflammatory and cytoprotective functions in the articular cartilage of monoiodoacetate-injected rats

Abstract

Downloads

References