Antioxidant and lipid-lowering effects of freeze-dried kimchi cabbage and onion mediated via inhibition of adipogenesis in 3T3-L1 adipocytes

Ye-Rang Yun; Wooje Lee; Sung Wook Hong

doi:10.29219/fnr.v69.11101

Ye-Rang Yun World Institute of Kimchi, Nam-Gu, Gwangju, Republic of Korea
Wooje Lee World Institute of Kimchi, Nam-Gu, Gwangju, Republic of Korea
Sung Wook Hong World Institute of Kimchi, Nam-Gu, Gwangju, Republic of Korea

DOI: https://doi.org/10.29219/fnr.v69.11101

Keywords: antioxidant effect;, freeze-drying, kimchi cabbage, lipid accumulation, obesity-associated mRNA/protein expression

Abstract

Background: Kimchi exhibits various beneficial effects on human health, which are ascribed to its ingredients, bioactive compounds, lactic acid bacteria, and metabolites.

Objective: To explore the antioxidant and lipid-lowering effects of individual ingredients of freeze-dried kimchi in 3T3-L1 adipocytes.

Design: The lipid-lowering effects of six kimchi ingredients were investigated using 3T3-L1 adipocytes. Their antioxidant activities, cytotoxicity, and the effect on triglyceride (TG) content, lipid accumulation, and obesity-associated biomarker expressions were examined.

Results: Freeze-dried ginger exhibited the highest antioxidant activity, followed by kimchi cabbage and onion. Freeze-dried garlic and green onion showed cytotoxicity, and the TG content in freeze-dried ginger-treated cells was similar to that of the control. Freeze-dried kimchi cabbage- and onion-treated cells exhibited increased antioxidant activities, low cell toxicity, and remarkable effects on the TG content. Selected freeze-dried kimchi cabbage and onion significantly inhibited lipid accumulation and decreased the expression of obesity-associated messenger RNA (mRNA) and proteins, with freeze-dried kimchi cabbage being more efficient (P < 0.05).

Discussion: The six kimchi ingredients showed differences in anti-obesity effects, and these effects may be related to antioxidant properties.

Conclusion: Freeze-dried kimchi cabbage exhibited the most pronounced antioxidant and lipid-lowering effects among the six kimchi ingredients tested, highlighting the potential applications of kimchi in obesity-associated metabolic pathway research.

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