Causal relationships between 25-hydroxyvitamin D levels and laryngeal cancer risk: A two-sample Mendelian randomization study

Dapeng Wang; Li Zhang; Yanfen Cui; Ruyuan Guo; Fuli Zhang; Junjie Zhang; Xiaotang Yang

doi:10.29219/fnr.v69.11489

Dapeng Wang Department of Radiation Oncology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, P.R. China.
Li Zhang Department of Head and Neck Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, P.R. China.
Yanfen Cui Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University No. 3 Workers New Street, Xinghualing District Taiyuan 030013, P.R. China.
Ruyuan Guo Department of Radiation Oncology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, P.R. China.
Fuli Zhang Department of Radiation Oncology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, P.R. China.
Junjie Zhang Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University No. 3 Workers New Street, Xinghualing District Taiyuan 030013, P.R. China.
Xiaotang Yang Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University

DOI: https://doi.org/10.29219/fnr.v69.11489

Keywords: laryngeal cancer, 25-hydroxyvitamin D, Mendelian randomization, single-nucleotide polymorphisms

Abstract

Background: The relationship between 25-hydroxyvitamin D (25(OH)D) levels and the risk of laryngeal cancer (LC) is unclear. This study aimed to explore the causal association between 25(OH)D levels and LC risk using the two-sample Mendelian randomization (MR) analysis.

Methods: Single-nucleotide polymorphisms for 25(OH)D levels and LC were extracted from published genome-wide association studies (GWAS) or the Medical Research Council Integrative Epidemiology Unit (MRC-IEU) Open GWAS project. Univariable MR and multivariable MR analyses were performed. Five MR methods including MR-Egger, weighted-median, inverse-variance weighted (IVW), simple mode, and weighted mode were applied.

Results: Univariable MR analysis identified the fact that genetically predicted higher levels of 25(OH)D were associated with lower odds of LC [IVW: (odds ratio (OR) = 0.9993, 95% confidence interval (CI), 0.9987–0.9999; P = 0.019)]. Multivariable MR analyses suggested that genetically predicted higher levels of 25(OH)D were correlated with lower risk of LC after adjusting for pack-years of cigarette smoking (CS) [IVW: (OR = 0.9993, 95% CI, 0.9987–0.9998; P = 0.006)] or both pack-years of CS and weekly alcoholic drinks [IVW: (OR = 0.9993, 95% CI, 0.9988–0.9998; P = 0.011)], but this was not significant after adjusting only for weekly alcoholic drinks [IVW: (OR = 0.9995, 95% CI, 0.9989–1.0001; P = 0.077)].

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