Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet

  • Najla Gooda Sahib Jambocus
  • Amin Ismail
  • Alfi Khatib
  • Fawzi Mahomoodally
  • Nazamid Saari
  • Muhammad Waseem Mumtaz
  • Azizah Abdul Hamid
Keywords: Morinda citrifolia, high fat diet, anti-obesity, pancreatic lipase, lipoprotein lipase, flavonoids


Background : Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile.

Design : Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. 1 H NMR and LCMS methods were employed for phytochemical profiling of MLE60.

Results : The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels . MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors . 1 Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant.

Conclusion : MLE60 shows promise as an anti-obesity agents and warrants further research.


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How to Cite
Gooda Sahib Jambocus N, Ismail A, Khatib A, Mahomoodally F, Saari N, Waseem Mumtaz M, Abdul Hamid A. <em>Morinda citrifolia</em&gt; L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet. fnr [Internet]. 2017Jul.27 [cited 2020Feb.23];610. Available from:
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