Marine fish peptides (collagen peptides) compound intake promotes wound healing in rats after cesarean section

  • Xue Peng Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China
  • Jinfeng Xu Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu; West China School of Medicine, Sichuan University, Chengdu, China
  • Yuan Tian Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu; West China School of Medicine, Sichuan University, Chengdu, China
  • Wenjun Liu Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China
  • Bing Peng Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China
Keywords: Cesarean section, Marine fish peptides, Rat uterus, Uterine scar, Wound healing


Background: Wound complications are a major source of morbidity after cesarean section (CS) and contribute to increased risks in subsequent pregnancies. In the present study, we aim to investigate the wound healing potential of a kind of oligopeptide compound, mainly derived from the marine fish peptides (MFPs), in rats after CS by biomechanical, biochemical, and histological methods.

Methods: Eighty-four pregnant Sprague–Dawleyrats were randomly assigned to four groups, namely the control group and 1.1, 2.2, and 4.4 mg/kg MFP groups, respectively. The MFPs or normal saline of the equal volume was intragastrically administered every morning on the second day after CS. On days 5, 10, and 15 after the surgery, seven rats from each group were randomly selected. The samples of skin wound and uterus were harvested and then used for the following experiments and analyses.

Results: Using the CS rat model, this study demonstrated that in the MFP groups, the skin tensile strength, uterine bursting pressure, and hydroxyproline (Hyp) were significantly higher than those in the control group at all three time points (P < 0.05). The formation of collagen and smooth muscle fibers and the expression of CD34 and connective tissue growth factor at the incision site were increasingly observed in the MFP groups (P < 0.05).

Conclusions: MFPs have a great potential to accelerate the process and quality of wound healing in rats after CS.


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How to Cite
Peng, X., Xu, J., Tian, Y., Liu, W., & Peng, B. (2020). Marine fish peptides (collagen peptides) compound intake promotes wound healing in rats after cesarean section. Food & Nutrition Research, 64.
Original Articles