A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: a randomized clinical trial
Background: Pregnancy-induced hypertension (PIH) is a disease characterized by high blood pressure detected after 20 weeks of pregnancy, affecting approximately 10% of pregnant women worldwide. Effective strategies are imperatively needed to prevent and treat PIH.
Methods: Subjects were required to consume 100 g mushroom daily from pre-pregnancy to the 20th week of gestation. The gestational hypertension and related primary and secondary outcomes of the mushroom diet (MD) group and placebo group were investigated to compare the intervention of a MD on the PIH and preeclampsia- associated maternal and child health conditions.
Results: A total of 582 and 580 subjects belonging to the MD group and placebo group were included for the analysis, respectively. Compared to the placebo, the MD significantly reduced the incidence of gestational hypertension (P = 0.023), preeclampsia (P = 0.014), gestational weight gain (P = 0.017), excessive gestational weight gain (P = 0.032) and gestational diabetes (P = 0.047). Stratified analysis showed that the MD lowered the risk of PIH for overweighed women (P = 0.036), along with the percentage of macrosomia (P = 0.007).
Conclusion: An MD could serve as a preventative strategy for lowering the risk of PIH and could control newborn birthweight while reducing comorbidities including gestational weight gain, diabetes etc.
- Henderson JRC. Pregnancy-induced hypertension. Clin Rev 2012; 22(5): 27–32.
- Ikem E, Halldorsson TI, Birgisdottir BE, Rasmussen MA, Olsen SF, Maslova E. Dietary patterns and the risk of pregnancy-associated hypertension in the Danish National Birth Cohort: a prospective longitudinal study. BJOG 2019; 126(5): 663–73. doi: 10.1111/1471-0528.15593
- Khaing W, Vallibhakara SA, Tantrakul V, Vallibhakara O, Rattanasiri S, McEvoy M, et al. Calcium and vitamin D supplementation for prevention of preeclampsia: a systematic review and network meta-analysis. Nutrients 2017; 9(10): 1141. doi: 10.3390/nu9101141
- Chen S, Li N, Mei Z, Ye R, Li Z, Liu J, et al. Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: a randomized clinical trial. Clin Nutr 2019; 38(1): 146–51. doi: 10.1016/j.clnu.2018.01.029
- Barakat R, Pelaez M, Cordero Y, Perales M, Lopez C, Coteron J, et al. Exercise during pregnancy protects against hypertension and macrosomia: randomized clinical trial. Am J Obstet Gynecol 2016; 214(5): 649.e1–8. doi: 10.1016/j.ajog.2015.11.039
- Rayman MP, Searle E, Kelly L, Johnsen S, Bodman-Smith K, Bath SC, et al. Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial. Br J Nutr 2014; 112(1): 99–111. doi: 10.1017/s0007114514000531
- Kerley RN, McCarthy C, Kell DB, Kenny LC. The potential therapeutic effects of ergothioneine in pre-eclampsia. Free Radic Biol Med 2018; 117: 145–57. doi: 10.1016/j.freeradbiomed.2017.12.030
- Podymow T, August P. New evidence in the management of chronic hypertension in pregnancy. Semin Nephrol 2017; 37(4): 398–403. doi: 10.1016/j.semnephrol.2017.05.012
- Lu Y, Chen R, Cai J, Huang Z, Yuan H. The management of hypertension in women planning for pregnancy. Br Med Bull 2018; 128(1): 75–84. doi: 10.1093/bmb/ldy035
- Feeney MJ, Dwyer J, Hasler-Lewis CM, Milner JA, Noakes M, Rowe S, et al. Mushrooms and Health Summit proceedings. J Nutr 2014; 144(7): 1128s–36s. doi: 10.3945/jn.114.190728
- Poddar KH, Ames M, Hsin-Jen C, Feeney MJ, Wang Y, Cheskin LJ. Positive effect of mushrooms substituted for meat on body weight, body composition, and health parameters. A 1-year randomized clinical trial. Appetite 2013; 71: 379–87. doi: 10.1016/j.appet.2013.09.008
- Mujic I, Zekovic Z, Vidovic S, Radojkovic M, Zivkovic J, Godevac D. Fatty acid profiles of four wild mushrooms and their potential benefits for hypertension treatment. J Med Food 2011; 14(11): 1330–7. doi: 10.1089/jmf.2010.0352
- Podymow T, Joseph G. Preconception and pregnancy management of women with diabetic nephropathy on angiotensin converting enzyme inhibitors. Clin Nephrol 2015; 83(2): 73–9. doi: 10.5414/cn108391
- Zhang P, Roytrakul S, Sutheerawattananonda M. Production and purification of glucosamine and angiotensin-I converting enzyme (ACE) inhibitory peptides from mushroom hydrolysates. J Funct Foods 2017; 36: 72–83. doi: 10.1016/j.jff.2017.06.049
- Brown CM, Garovic VD. Mechanisms and management of hypertension in pregnant women. Curr Hypertens Rep 2011; 13(5): 338–46. doi: 10.1007/s11906-011-0214-y
- Roberts JM, Lain KY. Recent insights into the pathogenesis of pre-eclampsia. Placenta 2002; 23(5): 359–72. doi: 10.1053/plac.2002.0819
- Chandrasekaran S, Levine LD, Durnwald CP, Elovitz MA, Srinivas SK. Excessive weight gain and hypertensive disorders of pregnancy in the obese patient. J Matern Fetal Neonatal Med 2015; 28(8): 964–8. doi: 10.3109/14767058.2014.939624
- O’Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of preeclampsia: a systematic overview. Epidemiology 2003; 14(3): 368–74. doi: 10.1097/00001648-200305000-00020
- Alves E, Azevedo A, Rodrigues T, Santos AC, Barros H. Impact of risk factors on hypertensive disorders in pregnancy, in primiparae and multiparae. Ann Hum Biol 2013; 40(5): 377–84. doi: 10.3109/03014460.2013.793390
- He Y, Wen S, Tan H, Zhou S, Guo Y, Wang S, et al. [Study on the influence of pregnancy-induced hypertension on neonatal birth weight and its interaction with other factors]. Zhonghua Liu Xing Bing Xue Za Zhi 2014; 35(4): 397–400.
- Agriculture USDo. National Nutrient Database for standard reference. Release 26. Washington, DC: U.S. Department of Agriculture; 2013.
- Wang LC, Wang SE, Wang JJ, Tsai TY, Lin CH, Pan TM, et al. In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid beta-protein-induced neurotoxicity and memory impairment. Appl Microbiol Biotechnol 2012; 94(6): 1505–19. doi: 10.1007/s00253-012-3941-3
- Bennett L, Sheean P, Zabaras D, Head R. Heat-stable components of wood ear mushroom, Auricularia polytricha (higher Basidiomycetes), inhibit in vitro activity of beta secretase (BACE1). Int J Med Mushrooms 2013; 15(3): 233–49. doi: 10.1615/intjmedmushr.v15.i3.20
- Shin A, Kim J, Lim SY, Kim G, Sung MK, Lee ES, et al. Dietary mushroom intake and the risk of breast cancer based on hormone receptor status. Nutr Cancer 2010; 62(4): 476–83. doi: 10.1080/01635580903441212
- Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, et al. Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res 2006; 66(24): 12026–34. doi: 10.1158/0008-5472.Can-06-2206
- Signoretto C, Burlacchini G, Marchi A, Grillenzoni M, Cavalleri G, Ciric L, et al. Testing a low molecular mass fraction of a mushroom (Lentinus edodes) extract formulated as an oral rinse in a cohort of volunteers. J Biomed Biotechnol 2011; 2011: 857987. doi: 10.1155/2011/857987
This work is licensed under a Creative Commons Attribution 4.0 International License
Authors retain copyright of their work, with first publication rights granted to SNF Swedish Nutrition Foundation.