Serum unmetabolized folic acid in a nationally representative sample of adults ≥ 60 years in the United States, 2001-2002

  • Regan L. Bailey National Insitutes of Health
  • James L. Mills National Institutes of Health
  • Elizabeth A. Yetley National Institutes of Health
  • Jaime J. Gahche National Center for Health Statistics
  • Chrisitne M. Pfeiffer Centers for Disease Control and Prevention
  • Johanna T. Dwyer National Institutes of Health
  • Kevin W. Dodd National Institutes of Health
  • Christopher T. Sempos National Institutes of Health
  • Joseph M. Beth National Institutes of Health
  • Mary Frances Picciano National Institutes of Health
Keywords: Folic Acid, Folate, NHANES, Folic Acid Fortification,

Abstract

Folic acid is a compound that does not occur naturally in food but is added as a fortificant and dietary supplement. When it is ingested it is converted into forms of reduced folate that are identical to those arising from ingestion of naturally occurring folate in foods; however, some folic acid may appear unmetabolized in the serum (1, 2). Very little is known about its metabolism and biological effects. Folic acid fortification increased dietary intakes of folic acid (3) and blood folate levels in the United States (4). Some (5-9) but not all (10-12) research suggests that high folic acid intakes may promote the growth of pre-existing cancers or malignant lesions.

Keywords: folic acid; folate; NHANES; folic acid fortification

(Published: 2 April 2012)

Citation: Food & Nutrition Research 2012. 56 5616 - DOI: 10.3402/fnr.v56i0.5616

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Published
2012-04-02
How to Cite
1.
Bailey R, Mills J, Yetley E, Gahche J, Pfeiffer C, Dwyer J, Dodd K, Sempos C, Beth J, Picciano MF. Serum unmetabolized folic acid in a nationally representative sample of adults ≥ 60 years in the United States, 2001-2002. fnr [Internet]. 2012Apr.2 [cited 2019Jun.25];00. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/510
Section
Vitamin Supplement