Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment

  • Miguel Guzman-Rivero Universidad Mayor de San Simón, Bolivia and Lund University, Sweden
  • Ernesto Rojas Universidad Mayor de San Simón, Bolivia
  • Aleida Verduguez-Orellana Universidad Mayor de San Simón, Bolivia
  • Henry Pardo Universidad Mayor de San Simón, Bolivia
  • Mary Cruz Torrico Universidad Mayor de San Simón, Bolivia
  • Lieselotte Cloetens Lund University, Sweden
  • Björn Åkesson Lund University and Skåne University Hospital, Sweden
  • Edgar Sejas Universidad Mayor de San Simón, Bolivia
Keywords: Health claims

Abstract

Background: The role of micronutrient status for the incidence and clinical course of cutaneous leishmaniasis is not much studied. Still zinc supplementation in leishmaniasis has shown some effect on the clinical recovery, but the evidence in humans is limited.

Objective: To compare biochemical nutritional status in cutaneous leishmaniasis patients with that in controls and to study the effects of zinc supplementation for 60 days.

Design: Twenty-nine patients with cutaneous leishmaniasis were treated with antimony for 20 days. Fourteen of them got 45 mg zinc daily and 15 of them got placebo. Biomarkers of nutritional and inflammatory status and changes in size and characteristics of skin lesions were measured.

Results: The level of transferrin receptor was higher in patients than in controls but otherwise no differences in nutritional status were found between patients and controls. No significant effects of zinc supplementation on the clinical recovery were observed as assessed by lesion area reduction and characteristics or on biochemical parameters.

Conclusions: It is concluded that nutritional status was essentially unaffected in cutaneous leishmaniasis and that oral zinc supplementation administered together with intramuscular injection of antimony had no additional clinical benefit.

Keywords: nutritional biomarkers; zinc supplementation; cutaneous leishmaniasis; antimony treatment; clinical chemistry (Published: 6 November 2014)

Citation: Food & Nutrition Research 2014, 58: 23353 - http://dx.doi.org/10.3402/fnr.v58.23353

Responsible Editor: Asim Duttaroy, University of Oslo, Norway.

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Author Biographies

Miguel Guzman-Rivero, Universidad Mayor de San Simón, Bolivia and Lund University, Sweden

Instituto de Investigaciones Bio-Médicas (IIBISMED), and Centro Universitario de Medicina Tropical (CUMETROP), Universidad Mayor de San Simón  

Biomedical Nutrition, Pure and Applied Biochemistry, Lund University

Ernesto Rojas, Universidad Mayor de San Simón, Bolivia
Instituto de Investigaciones Bio-Médicas (IIBISMED), and Centro Universitario de Medicina Tropical (CUMETROP), Universidad Mayor de San Simón
Aleida Verduguez-Orellana, Universidad Mayor de San Simón, Bolivia
Instituto de Investigaciones Bio-Médicas (IIBISMED), and Centro Universitario de Medicina Tropical (CUMETROP), Universidad Mayor de San Simón
Henry Pardo, Universidad Mayor de San Simón, Bolivia
Instituto de Investigaciones Bio-Médicas (IIBISMED), and Centro Universitario de Medicina Tropical (CUMETROP), Universidad Mayor de San Simón
Mary Cruz Torrico, Universidad Mayor de San Simón, Bolivia
Instituto de Investigaciones Bio-Médicas (IIBISMED), Universidad Mayor de San Simón
Lieselotte Cloetens, Lund University, Sweden
Biomedical Nutrition, Pure and Applied Biochemistry, Lund University
Björn Åkesson, Lund University and Skåne University Hospital, Sweden

Biomedical Nutrition, Pure and Applied Biochemistry, Lund University

Department of Clinical Nutrition, Skåne University Hospital

Edgar Sejas, Universidad Mayor de San Simón, Bolivia
Instituto de Investigaciones Bio-Médicas (IIBISMED), Universidad Mayor de San Simón
Published
2014-11-06
How to Cite
Guzman-Rivero, M., Rojas, E., Verduguez-Orellana, A., Pardo, H., Torrico, M. C., Cloetens, L., Åkesson, B., & Sejas, E. (2014). Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment. Food & Nutrition Research. https://doi.org/10.3402/fnr.v58.23353
Section
Original Articles