Açaí (Euterpe oleracea) pulp-enriched diet induces anxiolytic-like effects and improves memory retention

  • Tayana Silva de Carvalho Laboratório de Neurofarmacologia Experimental
  • Alódia Brasil 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Luana K. R. Leão 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Danielle Valente Braga 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil
  • Mateus Santos-Silva 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Nadyme Assad 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Waldo Lucas Luz 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Evander de Jesus O. Batista 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Gilmara de Nazareth Tavares Bastos 4Laboratório de Neuroinflamação, Universidade Federal do Pará, Belém, Pará, Brazil
  • Karen Renata Matos Herculano Oliveira 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
  • Domingos Luiz Wanderley Picanço Diniz 5Universidade Federal do Oeste do Pará, Santarém, Pará, Brazil
  • Anderson Manoel Herculano 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.
Keywords: Anxiety, memory, oxidative stress, hippocampus, polyunsaturated diet

Abstract

Background: Açaí (Euterpe oleracea) has a rich nutritional composition, showing nutraceutical and protective effects in several organs. In this study, the effects of an açaí-enriched diet on motor performance, anxiety-like behavior, and memory retention were deeply investigated.

Methods: Eight-week male Wistar rats were fed with an Euterpe oleracea (EO) pulp-enriched diet, an olive oil-enriched (OO) diet (polyunsaturated fatty acid [PUFA] fat control diet), or a chow diet for 31 days (28 days pre-treatment and 3 days during behavioral tests). Afterward, animals were submitted to a battery of behavioral tests to evaluate spontaneous motor behavior (open-field test), anxiety-like behavior (elevated plus maze and open-field test), and memory retention (step-down). Oxidative stress in the hippocampus was evaluated by a lipid peroxidation assay.

Results: EO-enriched diet did not influence the body weight and food intake but increased the glucose plasmatic level after 31 days under this diet. However, a similar fat-enriched diet stimulated a marked weight gain and reduced the food intake, followed by changes in the plasmatic lipid markers. EO-enriched diet preserved the motor spontaneous performance, increased the exploration in the aversive environment (anxiolytic-like effects), and elevated the latency to step-down (improved memory retention). The EO-enriched diet also reduced the level of lipid peroxidation in the hippocampus. These positive effects of EO-enriched diet can greatly support the usage of this diet as a preventive therapy.

Conclusion: Taken together, the current study suggests that Euterpe oleracea-enriched diet promotes anxiolytic-like effects and improves memory consolidation, possibly due to the reduced levels of lipid peroxidation in the hippocampus.

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Author Biographies

Alódia Brasil, 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.

2Laboratório de Neurologia Tropical, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil.

Evander de Jesus O. Batista, 1Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, Pará, Brazil.

3Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil.

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Published
2022-11-02
How to Cite
Silva de Carvalho T., Brasil A., Leão L. K. R., Valente Braga D., Santos-Silva M., Assad N., Lucas Luz W., de Jesus O. Batista E., de Nazareth Tavares Bastos G., Renata Matos Herculano Oliveira K., Luiz Wanderley Picanço Diniz D., & Manoel Herculano A. (2022). Açaí (<em>Euterpe oleracea</em&gt;) pulp-enriched diet induces anxiolytic-like effects and improves memory retention. Food & Nutrition Research, 66. https://doi.org/10.29219/fnr.v66.8851
Section
Original Articles