Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects

  • Xavier Deplanque
  • Delphine Muscente-Paque
  • Eric Chappuis Naturalpha
Keywords: Metabolic syndrome, Health claims


Background: Low-density lipoprotein (LDL) oxidation is a risk factor for atherosclerosis. Lycopene and tomato-based products have been described as potent inhibitors of LDL oxidation.

Objectives: To evaluate the effect of a 2-week supplementation with a carotenoid-rich tomato extract (CRTE) standardized for a 1:1 ratio of lycopene and phytosterols, on post-prandial LDL oxidation after a high-fat meal.

Design: In a randomized, double-blind, parallel-groups, placebo-controlled study, 146 healthy normal weight individuals were randomly assigned to a daily dose of CRTE standardized for tomato phytonutrients or placebo during 2 weeks. Oxidized LDL (OxLDL), glucose, insulin, and triglyceride (TG) responses were measured for 8 h after ingestion of a high-fat meal before and at the end of intervention.

Results: Plasma lycopene, phytofluene, and phytoene were increased throughout the study period in the CRTE group compared to placebo. CRTE ingestion significantly improved changes in OxLDL response to high-fat meal compared to placebo after 2 weeks (p<0.0001). Changes observed in glucose, insulin, and TG responses were not statistically significant after 2 weeks of supplementation, although together they may suggest a trend of favorable effect on metabolic outcomes after a high-fat meal.

Conclusions: Two-week supplementation with CRTE increased carotenoids levels in plasma and improved oxidized LDL response to a high-fat meal in healthy normal weight individuals.

Keywords: cardiovascular; carotenoid-rich tomato extract; oxidative stress; tomato; oxidized LDL

(Published: 4 October 2016)

Citation: Food & Nutrition Research 2016, 60: 32537 -


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Author Biography

Eric Chappuis, Naturalpha
Consulting, Director
How to Cite
Deplanque X., Muscente-Paque D., & Chappuis E. (2016). Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects. Food & Nutrition Research, 60.
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