Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium

  • Susanne Bügel
  • Erik H. Larsen
  • Jens J. Sloth
  • Knut Flytlie
  • Kim Overvad
  • Lars C. Steenberg
  • Sven Moesgaard
Keywords: selenium yeast; stable isotope; humans; pharmacokinetics; absorption; excretion

Abstract

Objective: The purpose of this study was to evaluate the pharmacokinetics of a single dose of Selenium (Se) from yeast given to humans with a habitual long-term daily intake at a supra-nutritional level. 

Methods: Twelve healthy males with a daily supplemental intake of 300 µg Se as selenised yeast over 10 weeks were supplemented with a single dose of 327 µg as stable 77 Se incorporated into selenised yeast manufactured by the same standardised process (SelenoPrecise®, Pharma Nord, Denmark).

Results: Absorption of Se from 77 Se-enriched yeast was 89±4% and the retention was 74±6%. The 77 Se excretion from the single-dose was 47±15 µg in urine and 37±13 µg in faeces. The maximum, enriched 77 Se concentration in plasma was 9.8±1.5 µg/l and the time to maximum was 9.2 hours. The plasma halftime of 77 Se was longer with increasing time; 1.7 days for the initial phase (½-2 days), 3.0 days for the middle phase (2–3 days) and 11.1 days for the later phase (3–14 days).

Conclusion: The Se from the standardised Se-enriched yeast was well absorbed and retained in the body.

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Published
2008-02-12
How to Cite
1.
Bügel S, Larsen E, Sloth J, Flytlie K, Overvad K, Steenberg L, Moesgaard S. Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium. fnr [Internet]. 2008Feb.12 [cited 2019Jun.15];0(52). Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/1101
Section
Original Articles

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