Impact of cooking on the antioxidant activity of spice turmeric
Abstract
Curcuminoids, as the main ingredient of turmeric, are popularly used in food additives and condiments, and are widely accepted to be beneficial for human health for their antioxidant activity. However, curcuminoids are highly susceptible in terms of thermal-induced degradation, and curry is usually boiled, roasted, or fried in the use of food additives and condiments. Thus, it is interesting to explore the effect of cooking on the antioxidant activity of curcuminoids. In the present study, the total antioxidant capacity (T-AOC) of cooked curcuminoids (boiled curcuminoids, roasted curcuminoids, and fried curcuminoids) processed through three heating conditions, and their protective effects against oxidative damage to rat pheochromocytoma (PC12) cells, a well-established neuronal model, were evaluated. It was found that cooking slightly lowered the T-AOC of curcuminoids, with boiled curcuminoids being relatively stronger than roasted curcuminoids, and fried curcuminoids being the weakest form. Both boiled and roasted curcuminoids could significantly improve cell viability, mitigate intracellular accumulation of reactive oxygen species and reduce malondialdehyde activity, reduce caspase-3 and caspase-9 protein expression, and increase superoxide dismutase activity of PC12 cells compared with the control group. In comparison with parent curcuminoids, the protective effects of cooked curcuminoids got relatively lower overall, with boiled curcuminoids being relatively stronger than roasted curcuminoids. In conclusion, the cooked curcuminoids, including boiled and roasted forms, still have antioxidant and neuroprotective activity.
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References
- Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 2008; 76: 1037–1636. doi: 10.1016/j.bcp.2008.08.008.
- Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 2009; 30: 85–94. doi: 10.1016/j.tips.2008.11.002.
- Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, et al. Chronic diseases, inflammation, and spices: how are they linked?. J Transl Med 2018; 16: 14. doi: 10.1186/s12967-018-1381-2.
- Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets 2011; 12: 332–347. doi: 10.2174/138945011794815356.
- Shen L, Ji HF. The pharmacology of curcumIn: is it the degradation products?. Trends Mol Med 2012; 18: 138–144. doi: 10.1016/j.molmed.2012.01.004.
- Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal 1997; 15: 1867–1876. doi: 10.1016/S0731-7085(96)02024-9.
- Lin JK, Pan MH, Lin-shiau SY. Recent studies on the biofunctions and biotransformations of curcumin. Biofactors 2000; 13: 153–158. doi: 10.1002/biof.5520130125.
- Ji HF, Shen L. Can improving bioavailability improve the bioactivity of curcumin?. Trends Pharmacol Sci 2014; 35: 265–266. doi: 10.1016/j.tips.2014.04.001.
- Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007; 595: 105–125. doi: 10.1007/978-0-387-46401-53.
- Shen L, Ji HF. Theoretical study on physicochemical properties of curcumin. Spectrochim. Spectrochim Acta A Mol Biomol Spectrosc 2007; 67: 619–623. doi: 10.1016/j.saa.2006.08.018.
- Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, et al. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic Biol Med 2007; 43: 568–580. doi: 10.1016/j.freeradbiomed.2007.05.009.
- Costa IM, Freire MAM, Cavalcanti JRLP, Araujo DP, Norrara B, RosaI MMM, et al. Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer’s disease: a systematic review. Curr Neuropharmacol 2018; 16: 0. doi: 10.2174/0929867325666180117112610.
- Goozee KG, Shah TM, Sohrabi HR, Rainey-Smith SR, Brown B, Verdile G, et al. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease. Br J Nutr 2016; 115: 449–465. doi: 10.1017/S0007114515004687.
- Tang M, Taghibiglou C. The mechanisms of action of curcumin in Alzheimer’s disease. J Alzheimers Dis 2017; 58: 1003–1016. doi: 10.3233/JAD-170188.
- Lim GP, Chu T, Yang F. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Neuroscience 2001; 21: 8370–8377. doi: 10.1523/JNEUROSCI.21-21-08370.2001.
- Shen L, Liu CC, An CY, Ji HF. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci Rep 2016; 6: 20872. doi: 10.1038/srep20872.
- Chandra V, Pandav R, Dodge HH, Johnston JM, Belle SH, DeKosky ST, et al. Incidence of Alzheimer’s disease in a rural community in India: the Indo-US study. Neurology 2001; 57: 985–993. doi: 10.1212/WNL.57.6.985.
- Vas CJ, Pinto C, Panikker D, Noronha S, Deshpande N, Kulkarni L, et al. Prevalence of dementia in an urban Indian population. Int Psychogeriatr 2001; 13: 439–450. doi: 10.1017/S1041610201007852.
- Marchiani A, Rozzo C, Fadda A, Delogu G, Ruzza P. Curcumin and curcumin-like molecules: from spice to drugs. Curr Med Chem 2014; 21: 204–222. doi: 10.2174/092986732102131206115810.
- Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787–795. doi: 10.1038/nature05292.
- Tonnies E, Trushina E. Oxidative stress, synaptic dysfunction, and Alzheimer’s disease. J Alzheimer’s Dis 2017; 57: 1105–1121. doi: 10.3233/JAD-161088.
- Barnham KJ, Masters CL, Bush AI, Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004; 3: 205–214. doi: 10.1038/nrd1330.
- Boettler U, Sommerfeld K, Volz N, Pahlke G, Teller N, Somoza V, et al. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J Nutr Biochem 2011; 22: 426–440. doi: 10.1016/j.jnutbio.2010.03.011.
- Boettler U, Volz N, Pahlke G, Teller N, Kotyczka C, Somoza V, et al. Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Mol Nutr Food Res 2011; 55: 798–802. doi: 10.1002/mnfr.201100115.
- Dahmke IN, Boettcher SP, Groh M, Mahlknecht U. Cooking enhances curcumin anti-cancerogenic activity through pyrolytic formation of ‘deketene curcumin’. Food Chem 2014; 26: 514–519. doi: 10.1016/j.foodchem.2013.11.102.
- Suresh D, Gurudutt KN, Srinivasan K. Degradation of bioactive spice compound: curcumin during domestic cooking. Eur Food Res Technol 2009; 228: 807–812. doi: 10.1007/s00217-008-0993-9.
- Hamaguchi T, Ono K, Yamada M. Review: curcumin and Alzheimer’s disease. CNS Neurosci Ther 2010; 16: 285–297. doi: 10.1111/j.1755-5949.2010.00147.x.
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