A 12-week, randomized, double-blind study to evaluate the efficacy and safety of liver function after using fermented ginseng powder (GBCK25)

  • Su-Jin Jung Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea; and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea https://orcid.org/0000-0003-1103-7477
  • Ji-Hyun Hwang Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea
  • Soo-Hyun Park Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea
  • Eun-Kyung Choi Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea; and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea
  • Ki-Chan Ha Healthcare Claims & Management Incorporation, Jeonju, Republic of Korea
  • Hyang-Im Baek Healthcare Claims & Management Incorporation, Jeonju, Republic of Korea
  • Dong-Gue Shin Research & Development Center of GENERAL BIO Co., Ltd, Namwon, Jeollabuk-Do, Republic of Korea
  • Jeong-Hun Seo Research & Development Center of GENERAL BIO Co., Ltd, Namwon, Jeollabuk-Do, Republic of Korea
  • Soo-Wan Chae Department of Pharmacology, Chonbuk National University, Medical School, Jeonju, Republic of Korea https://orcid.org/0000-0003-3660-8272
Keywords: fermented ginseng, liver function, gamma-glutamyl transferase, hs-CRP, anti-fatigue

Abstract

Popular scientific summary
  • We confirmed significant decreases in GGT and hs-CRP levels in male subjects suspected of non-alcoholic liver disease as a result of supplementation with 125 mg of GBCK25 (low dose).
  • We found significant improvements in fatigue score with intake of 500 mg of GBCK25 (high dose).
  • GBCK25 supplementation has beneficial effects on liver function.
 

Background: Recently, clinical research has suggested that red ginseng components play a role in liver protection and combating fatigue. However, fermented ginseng has not been analyzed for liver-protective or anti-fatigue effects.

Objective: This study evaluates the positive effects of fermented ginseng powder (GBCK25) on liver function.

Methods: Ninety participants with elevated alanine aminotransferase levels (35 ≤ ALT ≤1 05 IU/L) were randomized to one of three groups. The participants were treated with GBCK25 tablets at a dose of 500 mg/day (high dose), 125 mg/day (low dose), or placebo group daily for 12 weeks. The primary outcomes included changes in ALT and gamma-glutamyl transferase (GGT) levels. The secondary outcomes included changes in aspartate amino-transferase (AST), high-sensitivity C-reactive protein (hs-CRP), multidimensional fatigue scale, lipid profile, and antioxidant markers.

Results: In male subjects, after 12 weeks of low-dose GBCK25 (125 mg) supplementation, the GGT (P = 0.036) and hs-CRP (P = 0.021) levels decreased significantly more than those in the placebo group. High-dose GBCK25 (500 mg) supplementation significantly decreased the fatigue score compared with the placebo group. There were no clinically significant differences between the groups when studying any safety parameter.

Conclusion: Our results suggest that GBCK25 supplementation has beneficial effects on liver function.

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References


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Published
2020-04-06
How to Cite
Jung, S.-J., Hwang, J.-H., Park, S.-H., Choi, E.-K., Ha, K.-C., Baek, H.-I., Shin, D.-G., Seo, J.-H., & Chae, S.-W. (2020). A 12-week, randomized, double-blind study to evaluate the efficacy and safety of liver function after using fermented ginseng powder (GBCK25). Food & Nutrition Research, 64. https://doi.org/10.29219/fnr.v64.3517
Section
Original Articles