Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial

  • Chi Zhang Department of Nephrology, Xuzhou Medical University; Department of Nephrology, The Affiliated Suqian Hospital of Xuzhou Medical University, Jiangsu, China
  • Chang Ge Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Jiangsu, China
  • Junsheng Wang Department of Nephrology, The Affiliated Suqian Hospital of Xuzhou Medical University, Jiangsu, China
  • Dong Sun Department of Nephrology, Xuzhou Medical University; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Jiangsu, China
Keywords: fish oil; hemodialysis; PEW; supplement


Background: Supplementation of fish oil has been shown to exert beneficial effects in patients undergoing hemodialysis. The aim of this study was to investigate the efficacy of fish oil in improving the quality of life of these patients through a randomized, double-blinded clinical trial.

Methods: Among the 103 patients enrolled in the study, a total of 74 patients were randomized to receive fish oil (intervention group) or placebo (n=37 per group). Patients received identical soft-gel capsules, with each capsule containing either 1000 mg fish oil or placebo for 4 months. Personnel responsible for data collection and analyses were blinded to the grouping.

Results: The reduction of protein-energy wasting (PEW) in the intervention group was significantly more prominent compared to the placebo group (P=0.023). The intervention group demonstrated significant increase in midarm circumference, arm muscle circumference, and triceps skinfold thickness after fish oil intake. The intervention group also exhibited significant differences from the placebo group in creatinine, uric acid, and serum calcium levels. Significant improvement was seen regarding the physical role and energy/figure in the intervention group.

Conclusions: Our study demonstrated that fish oil intake in patient undergoing hemodialysis can significantly reduce PEW, and improve physical and biochemical parameters and quality of life, which could provide guidance to clinical management of these patients.


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How to Cite
Zhang, C., Ge, C., Wang , J., & Sun, D. (2020). Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial. Food & Nutrition Research, 64. https://doi.org/10.29219/fnr.v64.4450
Original Articles