Lactase persistence and milk consumption are associated with body height in Swedish preadolescents and adolescents

  • Ricardo Almon
  • Torbjörn K. Nilsson
  • Michael Sjöström
  • Peter Engfeldt
Keywords: LCT-13910 C>T polymorphism, body height, milk consumption, parental body height

Abstract

Background: Body height is a classic polygenic trait. About 80%-90% of height is inherited and 10%-20% owed to environmental factors, of which the most important ones are nutrition and diseases in preadolescents and adolescents. Objective: The aim of this study was to explore potential relations between the LCT (lactase) C>T-13910 polymorphism, milk consumption, and body height in a sample of Swedish preadolescents and adolescents. Design: In a cross-sectional study, using a random sample of preadolescents and adolescents (n=597), dietary intakes were determined. Anthropometric measurements including sexual maturity (Tanner stage) and birth weight were assessed. Parental body height and socio-economic status (SES) were obtained by questionnaires. Genotyping for the LCT C>T-13910 polymorphism that renders individuals lactase persistent (LP) or lactase non-persistent (LNP) was performed by DNA sequencing. Stepwise backward multivariate linear regression was used. Results: Milk consumption was significantly and positively associated with body height (Β=0.45; 95% CI: 0.040, 0.87, p=0.032). Adjustments were performed for sex, parental height, birth weight, body mass index (BMI), SES, and Tanner stage. This model explains 90% of the observed variance of body height (adjusted R2=0.89). The presence of the -13910 T allele was positively associated with body height (Β =2.05; 95% CI: 0.18, 3.92, p=0.032). Conclusions: Milk consumption is positively associated with body height in preadolescents and adolescents. We show for the first time that a nutrigenetic variant might be able to explain in part phenotypic variation of body height in preadolescents and adolescents. Due to the small sample size further studies are needed.

Keywords: LCT-13910 C>T polymorphism; body height; milk consumption; parental body height

(Published: 6 September 2011)

Citation: Food & Nutrition Research 2011, 55: 7253 - DOI: 10.3402/fnr.v55i0.7253

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Author Biographies

Ricardo Almon
Family Medicine Research Centre, School of Health and Medical Sciences, Örebro University, Box 1613, S 701 16 Örebro, Sweden, fax: + 46 19 6025797, Tel.: +46 19 6025789
Torbjörn K. Nilsson

Department of Laboratory Medicine, Clinical Chemistry, Örebro University Hospital, 70116 Örebro, Sweden

Michael Sjöström

Unit for Preventive Nutrition, Department of Biosciences and Nutrition, Karolinska Institute,

14157 Huddinge, Sweden

Peter Engfeldt
Family Medicine Research Centre, School of Health and Medical Sciences, Örebro University, Box 1613, S 701 16 Örebro, Sweden
Published
2011-09-06
How to Cite
1.
Almon R, Nilsson T, Sjöström M, Engfeldt P. Lactase persistence and milk consumption are associated with body height in Swedish preadolescents and adolescents. fnr [Internet]. 2011Sep.6 [cited 2019Jan.15];00. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/455
Section
Original Articles