The effect of immunonutrition (glutamine, alanine) on fracture healing

  • Abdullah Küçükalp Orthopaedic specialist
  • Kemal Durak Professor
  • Sarp Bayyurt Specialist
  • Gürsel Sönmez Professor
  • Muhammed S. Bilgen Associate professor
Keywords: Fracture Healing, Glutamine, Alanine, Immunonutrition, Antioxidant

Abstract

Background: There have been various studies related to fracture healing. Glutamine is an amino acid with an important role in many cell and organ functions. This study aimed to make a clinical, radiological, and histopathological evaluation of the effects of glutamine on fracture healing.

Methods: Twenty rabbits were randomly allocated into two groups of control and immunonutrition. A fracture of the fibula was made to the right hind leg. All rabbits received standard food and water. From post-operative first day for 30 days, the study group received an additional 2 ml/kg/day 20% L-alanine L-glutamine solution via a gastric catheter, and the control group received 2 ml/kg/day isotonic via gastric catheter. At the end of 30 days, the rabbits were sacrificed and the fractures were examined clinically, radiologically, and histopathologically in respect to the degree of union.

Results: Radiological evaluation of the control group determined a mean score of 2.5 according to the orthopaedists and 2.65 according to the radiologists. In the clinical evaluation, the mean score was 1.875 for the control group and 2.0 for the study group. Histopathological evaluation determined a mean score of 8.5 for the control group and 9.0 for the study group.

Conclusion: One month after orally administered glutamine–alanine, positive effects were observed on fracture healing radiologically, clinically, and histopathologically, although no statistically significant difference was determined.

Keywords: fracture healing; glutamine; alanine; immunonutrition; antioxidant 

(Published: 3 November 2014)

Citation: Food & Nutrition Research 2014, 58: 24998 - http://dx.doi.org/10.3402/fnr.v58.24998

Responsible Editor: Asim Duttaroy, University of Oslo, Norway.

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Author Biographies

Abdullah Küçükalp, Orthopaedic specialist

Gemlik State Hospital Gemlik Bursa Turkey

Kemal Durak, Professor
Uludag University Faculty of Medicine, Department of Orthopaedics and Traumatology,  Bursa, Turkey
Sarp Bayyurt, Specialist
Gaziantep Dr. Ersin Arslan State Hospital, Department of Orthopaedics and Traumatology, Gaziantep,  Turkey.
Gürsel Sönmez, Professor
Uludag University Faculty of Faculty of Veterinary Medicine, Department of Pathology, Bursa,  Turkey.
Muhammed S. Bilgen, Associate professor
Uludag University Faculty of Medicine, Department of Orthopaedics and Traumatology, Bursa, Turkey.
Published
2014-11-03
How to Cite
Küçükalp, A., Durak, K., Bayyurt, S., Sönmez, G., & Bilgen, M. S. (2014). The effect of immunonutrition (glutamine, alanine) on fracture healing. Food & Nutrition Research. https://doi.org/10.3402/fnr.v58.24998
Section
Original Articles