Genetic variation rs1121980 in the fat mass and obesity-associated gene (FTO) is associated with dietary intake in Koreans

  • Young Goh Department of Food Science and Nutrition, Keimyung University, Daegu, Korea
  • Jeong-Hwa Choi Department of Food Science and Nutrition, Keimyung University, Daegu, Korea
Keywords: food intake, food preference, FTO, genetic variation, Korean, obesity


Background: Fat mass and obesity-associated gene (FTO) is a well-known gene associated with body weight and obesity risk. Recent studies have suggested that genetic variations in FTO may play a role in the regulation of food preference and consumption. However, little is known with respect to Asian populations.

Objective: This study examined whether rs1121980 C > T in FTO is associated with food intake in Koreans.

Design: This study was performed using data from the Korean Genome and Epidemiology Study (Ansan/Ansung cohort). Dietary intake was determined using the semi-food frequency questionnaire, and the FTO rs1121980 genotypes of 6,262 individuals (3,049 males and 3,213 females) were analyzed along with sex and body mass index (BMI).

Result: Genetic variation did not show a significant association with the population’s energy-nutrient intake. However, female T allele carriers with BMI ≥ 25 consumed more blue fish and coffee, and their coffee creamer consumption was decisively higher than that of T allele non-carriers (Padjusted = 0.004). In males, the presence of the T allele showed a putative association with the consumption of sweets, snacks, and coffee creamer by the BMI level.

Conclusion: The FTO rs1121980 variation was associated with a preference for foods particularly high in fat (e.g. coffee creamer, blue fish, sweets, and snacks) in Koreans; these preferences varied by sex and BMI.


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How to Cite
Goh Y., & Choi J.-H. (2022). Genetic variation rs1121980 in the fat mass and obesity-associated gene (<em>FTO</em&gt;) is associated with dietary intake in Koreans. Food & Nutrition Research, 66.
Original Articles