Allium macrostemon whole extract ameliorates obesity-induced inflammation and endoplasmic reticulum stress in adipose tissue of high-fat diet-fed C57BL/6N mice

  • Juhae Kim Research Institute of Human Ecology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South Korea
  • Joo-Yeon Lee Research Institute of Human Ecology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South Korea; and Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South Korea
  • Choon Young Kim Research Institute of Human Ecology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South Korea; and Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South Korea
Keywords: adipose tissue, inflammation, endoplasmic reticulum stress, Allium macrostemon extract


Background: Obesity is a major risk factor for metabolic syndrome and a serious health concern worldwide. Various strategies exist to treat and prevent obesity, including dietary approaches using bioactive ingredients from natural sources.

Objective: This study aimed to investigate the anti-obesity effect of whole-plant Allium macrostemon (also called as long-stamen chive) extract (AME) as a potential new functional food.

Design: C57BL/6N mice were divided into three groups and fed either a control diet (CD), high-fat diet (HFD), or HFD with AME treatment (200 mg/kg BW daily) for 9 weeks. The mice in the CD and HFD groups were treated with vehicle control.

Results: AME supplementation reduced HFD-induced body weight gain, fat mass, and adipocyte size. AME suppressed peroxisome proliferator-activated receptor γ and fatty acid synthase mRNA expression, indicating reduced adipogenesis and lipogenesis in adipose tissue. In addition, AME lowered inflammation in adipose tissue, as demonstrated by the lower number of crown-like structures, mRNA, and/or protein expression of macrophage filtration markers, as well as pro-inflammatory cytokines, including F4/80 and IL-6. Endoplasmic reticulum stress was also alleviated by AME administration in adipose tissue. Several phenolic acids known to have anti-obesity effects, including ellagic acid, protocatechuic acid, and catechin, have been identified in AME.

Conclusion: By suppressing adipose tissue expansion and inflammation, AME is a potential functional food for the prevention and/or treatment of obesity and its complications.


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How to Cite
Kim J., Lee J.-Y., & Kim C. Y. (2023). <em>Allium macrostemon</em&gt; whole extract ameliorates obesity-induced inflammation and endoplasmic reticulum stress in adipose tissue of high-fat diet-fed C57BL/6N mice. Food & Nutrition Research, 67.
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