Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database

  • Xiaolei Zhang Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, China
  • Jiangwen Wu Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, China
  • Ting Wu Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, China
  • Liwen Guo Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, China
  • Ruiping Zhang Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, China
  • Xin Jin Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, China
DOI: https://doi.org/10.29219/fnr.v68.10338
Keywords: 25-Hydroxyvitamin D, severe headache or migraine, association, NHANES

Abstract

Objective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach.

Methods: A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables. Subgroup analysis, adjusting for confounding factors, was performed through stratified analysis to explore the association between 25(OH)D and severe headaches or migraines. Finally, a restricted cubic spline regression (RCS) was utilized to investigate the non-linear relationship between the variables.

Results: A total of 7,661 participants were included in this study, with an overall prevalence of severe headaches or migraines of 1,576/7,661 (22.3%). The results from all models consistently indicated a significant negative correlation between serum 25(OH)D levels and the risk of severe headaches or migraines (P < 0.05). Stratified analysis revealed that in the female population (odds ratios [OR]: 0.995, 95% CI: 0.991–0.998, P = 0.001), never smokers (OR: 0.991, 95% CI: 0.985–0.997, P = 0.003), and non-drinkers (OR: 0.993, 95% CI: 0.987–0.999, P = 0.022), the risk of severe headaches or migraines decreased with increasing serum 25(OH)D concentrations. RCS results demonstrated a linear relationship between serum 25(OH)D levels and the risk of severe headaches or migraines.

Conclusion: We discovered a negative correlation between serum 25(OH)D levels and the prevalence of severe headaches or migraines, particularly in females, non-smokers, and non-hypertensive individuals. Further clinical research is necessary to confirm these findings, establish causality, and explore potential preventive and therapeutic mechanisms for migraines.

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References


1.
GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019; 18(5): 459–80. doi: 10.1016/S1474-4422(18)30499-X


2.
Bahra A. Other primary headaches-thunderclap-, cough-, exertional-, and sexual headache. J Neurol 2020; 267 (5): 1554–66. doi: 10.1007/s00415-020-09728-0


3.
Dell’Isola GB, Tulli E, Sica R, Vinti V, Mencaroni E, Di Cara G, et al. The vitamin D role in preventing primary headache in adult and pediatric population. J Clin Med 2021; 10(24): 5983. doi: 10.3390/jcm10245983.


4.
Haneke H, Sulaiman S, Nickel S, Raffaelli B, Jansen JP, Kirchberger V. Changes in health-related quality of life in patients with therapy-resistant migraine during treatment with erenumab in an ambulatory care setting. J Clin Med 2023; 12(17): 5619. doi: 10.3390/jcm12175619


5.
Kim S, Seo J, Kim CH, Sung HK, Go HY, Jung WS, et al. Effect of herbal medicine (Jodeungsan) on migraine: a double-blind randomized clinical trial. Integr Med Res 2022; 11(4): 100885. doi: 10.1016/j.imr.2022.100885


6.
Buse DC, Loder EW, Gorman JA, Stewart WF, Reed, ML, Fanning KM, et al. Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache 2013; 53(8): 1278–99. doi: 10.1111/head.12150


7.
Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, Özge A, et al. Migraine: epidemiology and systems of care. Lancet 2021; 397(10283): 1485–95. doi: 10.1016/s0140-6736(20)32160-7


8.
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390(10100): 1211–59. doi: 10.1016/s0140-6736(17)32154-2


9.
Zhang N, Robbins MS. Migraine. Ann Intern Med 2023; 176(1): Itc1–itc16. doi: 10.7326/aitc202301170


10.
Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018; 38(1): 1–211. doi: 10.1177/0333102417738202


11.
Burch R, Rizzoli P, Loder E. The prevalence and impact of migraine and severe headache in the United States: figures and trends from government health studies. Headache 2018; 58(4): 496–505. doi: 10.1111/head.13281


12.
Lemmens J, De Pauw J, Van Soom T, Michiels S, Versijpt J, Van Breda E, et al. The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis. J Headache Pain 2019; 20(1): 16. doi: 10.1186/s10194-019-0961-8


13.
Di Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano S, Mele C, et al. Vitamin D and neurological diseases: an endocrine view. Int J Mol Sci 2017; 18(11): 2482. doi: 10.3390/ijms18112482


14.
Li R, Li Y, Fan Z, Liu Z, Lin J, He M. L-shaped association of serum 25-hydroxyvitamin D with all-cause and cardiovascular mortality in older people with chronic kidney disease: results from the NHANES database prospective cohort study. BMC Public Health 2023; 23(1): 1260. doi: 10.1186/s12889-023-16165-x


15.
Okazaki R, Ozono K, Fukumoto S, Inoue D, Yamauchi M, Minagawa M, et al. Assessment criteria for vitamin D deficiency/insufficiency in Japan: proposal by an expert panel supported by the Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research and the Japan Endocrine Society [Opinion]. J Bone Miner Metabol 2017; 35(1): 1–5. doi: 10.1007/s00774-016-0805-4


16.
Zhou R, Wang M, Huang H, Li W, Hu Y, Wu T. Lower vitamin D status is associated with an increased risk of ischemic stroke: a systematic review and meta-analysis. Nutrients 2018; 10(3): 277. doi: 10.3390/nu10030277


17.
Sun Q, Pan A, Hu FB, Manson JE, Rexrode KM. 25-hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysis. Stroke 2012; 43(6): 1470–77. doi: 10.1161/strokeaha.111.636910


18.
Tu WJ, Zhao SJ, Xu DJ, Chen H. Serum 25-hydroxyvitamin D predicts the short-term outcomes of Chinese patients with acute ischaemic stroke. Clin Sci (Lond) 2014; 126(5): 339–46. doi: 10.1042/cs20130284


19.
Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, Haghighi S, et al. Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci 2019; 40(12): 2459–77. doi: 10.1007/s10072-019-04021-z


20.
Rebecchi V, Gallo D, Princiotta Cariddi L, Piantanida E, Tabaee Damavandi P, Carimati F, et al. Vitamin D, chronic migraine, and extracranial pain: is there a link? Data from an observational study. Front Neurol 2021; 12: 651750. doi: 10.3389/fneur.2021.651750


21.
Liampas I, Siokas V, Brotis A, Dardiotis E. Vitamin D serum levels in patients with migraine: a meta-analysis. Rev Neurol 2020; 176 (7–8): 560–70. doi: 10.1016/j.neurol.2019.12.008


22.
Liampas I, Bourlios S, Siokas V, Aloizou AM, Dervenis P, Nasios G, et al. Vitamin D and tension-type headache: causal association or epiphenomenon? Int J Neurosci 2022; 134(5):441–51. doi: 10.1080/00207454.2022.2110495


23.
Hussein M, Fathy W, Abd Elkareem RM. The potential role of serum vitamin D level in migraine headache: a case-control study. J Pain Res 2019; 12: 2529–36. doi: 10.2147/JPR.S216314


24.
Zhang Y, Qiu H. Folate, vitamin B6 and vitamin B12 intake in relation to hyperuricemia. J Clin Med 2018; 7(8): 210. doi: 10.3390/jcm7080210


25.
Xiao Q, Cai B, Yin A, Huo H, Lan K, Zhou G, et al. L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study. BMC Med 2022; 20(1): 308. doi: 10.1186/s12916-022-02510-1


26.
Meng SH, Zhou HB, Li X, Wang MX, Kang LX, Fu JM, et al. Association between dietary iron intake and serum ferritin and severe headache or migraine. Front in Nutr 2021; 8: 685564. doi: 10.3389/fnut.2021.685564


27.
Stebbins RC, Noppert GA, Aiello AE, Cordoba E, Ward JB, Feinstein L. Persistent socioeconomic and racial and ethnic disparities in pathogen burden in the United States, 1999–2014. Epidemiol Infect 2019; 147: e301. doi: 10.1017/s0950268819001894


28.
Dong X, Li S, Sun J, Li Y, Zhang D. Association of coffee, decaffeinated coffee and caffeine intake from coffee with cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014. Nutrients 2020; 12(3): 840. doi: 10.3390/nu12030840


29.
Zhang Y, Liu W, Zhang W, Cheng R, Tan A, Shen S, et al. Association between blood lead levels and hyperlipidemiais: results from the NHANES (1999–2018). Front Public Health 2022; 10: 981749. doi: 10.3389/fpubh.2022.981749


30.
Ciardullo S, Grassi G, Mancia G, Perseghin G. Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 2022; 34(4): 365–71. doi: 10.1097/meg.0000000000002299


31.
Miao H, Liu Y, Tsai, TC, Schwartz J, Ji JS. Association between blood lead level and uncontrolled hypertension in the US population (NHANES 1999–2016). J Am Heart Assoc 2020; 9(13): e015533. doi: 10.1161/jaha.119.015533


32.
Zhao Y, Li H. Association of serum vitamin C with liver fibrosis in adults with nonalcoholic fatty liver disease. Scand J Gastroenterol 2022; 57(7): 872–7. doi: 10.1080/00365521.2022.2041085


33.
Victor TW, Hu X, Campbell JC, Buse DC, Lipton RB. Migraine prevalence by age and sex in the United States: a life-span study. Cephalalgia 2010; 30(9): 1065–72. doi: 10.1177/0333102409355601


34.
Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med 1989; 8(5): 551–61. doi: 10.1002/sim.4780080504


35.
Vikelis M, Spingos KC, Rapoport AM. A new era in headache treatment. Neurol Sci 2018; 39(Suppl 1): 47–58. doi: 10.1007/s10072-018-3337-y


36.
Song TJ, Chu MK, Sohn JH, Ahn HY, Lee SH, Cho SJ. Effect of vitamin D deficiency on the frequency of headaches in migraine. J Clin Neurol (Seoul, Korea) 2018; 14(3): 366–73. doi: 10.3988/jcn.2018.14.3.366


37.
Alipouri M, Amiri E, Hoseini R, Hezarkhani LA. Effects of eight weeks of aerobic exercise and vitamin D supplementation on psychiatric comorbidities in men with migraine and vitamin D insufficiency: a randomized controlled clinical trial. J Affect Disord 2023; 334: 12–20. doi: 10.1016/j.jad.2023.04.108


38.
Nowaczewska M, Wiciński M, Osiński S, Kaźmierczak H. The role of vitamin D in primary headache-from potential mechanism to treatment. Nutrients 2020; 12(1): 243. doi: 10.3390/nu12010243


39.
Hanci F, Kabakus N, Turay S, Bala KA, Dilek M. The role of obesity and vitamin D deficiency in primary headaches in childhood. Acta Neurol Belg 2020; 120(5): 1123–31. doi: 10.1007/s13760-019-01134-2


40.
Genizi J, Srugo I, Kerem NC. The cross-ethnic variations in the prevalence of headache and other somatic complaints among adolescents in Northern Israel. J Headache Pain 2013; 14(1): 21. doi: 10.1186/1129-2377-14-21


41.
Ahmad SR, Rosendale N. Sex and gender considerations in episodic migraine. Curr Pain Headache Rep 2022; 26(7): 505–16. doi: 10.1007/s11916-022-01052-8


42.
Rist PM, Winter AC, Buring JE, Sesso HD, Kurth T. Migraine and the risk of incident hypertension among women. Cephalalgia 2018; 38(12): 1817–24. doi: 10.1177/0333102418756865


43.
Liu Y, Shi L, Lin Y, Zhang M, Chen F, Li A, et al. Relationship between serum 25-hydroxyvitamin D and target organ damage in children with essential hypertension. J Hum Hypertens 2022; 36(7): 604–9. doi: 10.1038/s41371-021-00622-4


44.
Kuchulakanti PK, Chaudhuri JR, Annad U, Samala NR, Tallapaneni L, Balaraju B, et al. Association of serum 25-hydroxyvitamin D levels with primary hypertension: a study from south India. Hypertens Res 2020; 43(5): 389–95. doi: 10.1038/s41440-020-0394-4


45.
Farapti F, Fadilla C, Yogiswara N, Adriani M. Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis. F1000Res 2020; 9: 633. doi: 10.12688/f1000research.24623.3


46.
Nakamura H, Tsujiguchi H, Hara A, Kambayashi Y, Miyagi S, Thu Nguyen TT, et al. Dietary calcium intake and hypertension: importance of serum concentrations of 25-hydroxyvitamin D. Nutrients 2019; 11(4): 911. doi: 10.3390/nu11040911


47.
De la Guia-Galipienso F, Martinez-Ferran M, Vallecillo N, Lavie CJ, Sanchis-Gomar F, Pareja-Galeano H. Vitamin D and cardiovascular health. Clin Nutr 2021; 40(5): 2946–57. doi: 10.1016/j.clnu.2020.12.025


48.
Jorde R, Grimnes G. Lost relation between blood pressure and serum 25-hydroxyvitamin D. Blood Press 2019; 28(1): 64–73. doi: 10.1080/08037051.2018.1547628


49.
Sullivan DP, Martin PR, Boschen MJ. Psychological sleep interventions for migraine and tension-type headache: a systematic review and meta-analysis. Sci Rep 2019; 9(1): 6411. doi: 10.1038/s41598-019-42785-8


50.
Barber M, Pace A. Exercise and migraine prevention: a review of the literature. Curr Pain Headache Rep 2020; 24(8): 39. doi: 10.1007/s11916-020-00868-6


51.
Altamura C, Cecchi G, Bravo M, Brunelli N, Laudisio A, Caprio PD, et al. The healthy eating plate advice for migraine prevention: an interventional study. Nutrients. 2020; 12(6):1579. doi: 10.3390/nu12061579


52.
Ng QX, Venkatanarayanan N, Kumar L. A systematic review and meta-analysis of the efficacy of cognitive behavioral therapy for the management of pediatric migraine. Headache 2017; 57(3): 349–62. doi: 10.1111/head.13016


53.
Waldie KE, McGee R, Reeder AI, Poulton R. Associations between frequent headaches, persistent smoking, and attempts to quit. Headache 2008; 48(4): 545–52. doi: 10.1111/j.1526-4610.2007.01037.x


54.
Yuan S, Daghlas I, Larsson SC. Alcohol, coffee consumption, and smoking in relation to migraine: a bidirectional Mendelian randomization study. Pain 2022; 163(2): e342–e348. doi: 10.1097/j.pain.0000000000002360


55.
Thomas SD, Need AG, Nordin BE. Suppression of C-terminal telopeptide in hypovitaminosis D requires calcium as well as vitamin D. Calcif Tissue Int 2010; 86(5): 367–74. doi: 10.1007/s00223-010-9354-3


56.
Gallagher JC, Peacock M, Yalamanchili V, Smith LM. Effects of vitamin D supplementation in older African American women. J Clin Endocrinol Metab 2013; 98(3): 1137–46. doi: 10.1210/jc.2012-3106


57.
Mazahery H, Von Hurst PR. Factors affecting 25-hydroxyvitamin D concentration in response to vitamin D supplementation. Nutrients 2015; 7(7): 5111–42. doi: 10.3390/nu7075111


58.
Niramitmahapanya S, Harris SS, Dawson-Hughes B. Type of dietary fat is associated with the 25-hydroxyvitamin D3 increment in response to vitamin D supplementation. J Clin Endocrinol Metab 2011; 96(10): 3170–74. doi: 10.1210/jc.2011-1518


59.
Zhu P, Tong SL, Hao JH, Tao RX, Huang K, Hu WB, et al. Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers. J Nutr 2015; 145(6): 1232–8. doi: 10.3945/jn.114.208801


60.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911–30. doi: 10.1210/jc.2011-0385
Published
2024-12-09
How to Cite
Zhang X., Wu J., Wu T., Guo L., Zhang R., & Jin X. (2024). Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database. Food & Nutrition Research, 68. https://doi.org/10.29219/fnr.v68.10338
Issue
Vol 68 (2024)
Section
Original Articles
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