Zinc – a scoping review for Nordic Nutrition Recommendations 2023

  • Tor A. Strand Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; and Innlandet Hospital Trust, Lillehammer, Norway
  • Maria Mathisen Department of Medical Microbiology, Drammen Hospital, Drammen, Norway
Keywords: zinc, trace elements, cofactors, nutrition recommendations

Abstract

Zinc is essential for several biological processes including those critical for the immune system, DNA synthesis, cell division, and growth. Zinc is involved in the pathophysiology of chronic diseases and protects proteins and lipids from oxidative damage. Inadequate zinc intake and low plasma zinc concentration are associated to an increased risk of chronic diseases such as cardiovascular diseases and type 2 diabetes; however, the evidence is limited. Zinc deficiency increases the risk of infections and poor growth and may contribute to the high burden of infectious diseases and stunting in children living in low- and middle-income countries. The risk of zinc deficiency in the populations of the Nordic and Baltic countries is low.

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References


1.
Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ. Zinc: health effects and research priorities for the 1990s. Environ Health Pers 1994; 2: 5–46. doi: 10.1289/ehp.941025

2.
Brown KH, Rivera JA, Bhutta Z, Gibson RS, King JC, Lönnerdal B, et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 2004; 25(1 Suppl 2): S99–203. doi: 10.1177/156482650402500220

3.
Basnet S, Mathisen M, Strand TA. Oral zinc and common childhood infections – an update. J Trace Elem Med Biol 2015; 31: 163–6. doi: 10.1016/j.jtemb.2014.05.006

4.
Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. Can Med Assoc J 2012; 184(10): E551–61. doi: 10.1503/cmaj.111990

5.
Blomhoff R, Andersen R, Arnesen EK, Christensen JJ, Eneroth H, Erkkola M, et al. Nordic Nutrition Recommendations 2023. Copenhagen: Nordic Council of Ministers; 2023.

6.
Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, Høyer A, et al. The Nordic Nutrition Recommendations 2022 – principles and methodologies. Food Nutr Res 2020; 64: 4402. doi: 10.29219/fnr.v64.4402

7.
Høyer A, Christensen JJ, Arnesen EK, Andersen R, Eneroth H, Erkkola M, et al. The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews. Food Nutr Res 2021; 65: 7828. doi: 10.29219/fnr.v65.7828

8.
King JC, Brown KH, Gibson RS, Krebs NF, Lowe NM, Siekmann JH, et al. Biomarkers of Nutrition for Development (BOND) – zinc review. J Nutr 2015; 146(4): 858s–85s. doi: 10.3945/jn.115.220079

9.
King JC, Cousins RJ. Modern nutrition in health and disease. In: Ross AC, Caballero BC, Cousins RJ, Tucker KL, Ziegler TR, eds. Baltimore, MD: Lippincott Williams & Wilkins; 2014, p. 189–205.

10.
Chung CS, Stookey J, Dare D, Welch R, Nguyen TQ, Roehl R, et al. Current dietary zinc intake has a greater effect on fractional zinc absorption than does longer term zinc consumption in healthy adult men. Am J Clin Nutr 2008; 87(5): 1224–9. doi: 10.1093/ajcn/87.5.1224

11.
Sandstrom B, Sandberg AS. Inhibitory effects of isolated inositol phosphates on zinc absorption in humans. J Trace Elem Electrolytes Health Dis 1992; 6(2): 99–103.

12.
Lonnerdal B, Sandberg AS, Sandstrom B, Kunz C. Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. J Nutr 1989; 119(2): 211–4. doi: 10.1093/jn/119.2.211

13.
Brown KH, Engle-Stone R, Krebs NF, Peerson JM. Dietary intervention strategies to enhance zinc nutrition: promotion and support of breastfeeding for infants and young children. Food Nutr Bull 2009; 30(1 Suppl): S144–71. doi: 10.1177/15648265090301s108

14.
de Benoist B, Darnton-Hill I, Davidsson L, Fontaine O, Hotz C. Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG interagency meeting on zinc status indicators. Food Nutr Bull. 2007; 28(3 Suppl): S480–4. doi: 10.1177/15648265070283s306

15.
Gibson RS, Hess SY, Hotz C, Brown KH. Indicators of zinc status at the population level: a review of the evidence. Br J Nutr 2008; 99(Suppl 3): S14–23. doi: 10.1017/s0007114508006818

16.
EFSA NDA Panel (EFSA Panel on Dietetic Products NaA. Scientific opinion on dietary reference values for zinc. EFSA J. 2014; 12(10): 3844. doi: 10.2903/j.efsa.2014.3844

17.
Lemming EW, Pitsi T. The Nordic Nutrition Recommendations 2022 – food consumption and nutrient intake in the adult population of the Nordic and Baltic countries. Food Nutr Res 2022; 66: 8572. doi: 10.29219/fnr.v66.8572

18.
(VKM) NSCfFS. Assessment of zinc intake in relation to tolerable upper intake levels. Opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy of the Norwegian Scientific Committee for Food Safety. Oslo, Norway: VKM; 2017.

19.
Prasad AS. Zinc deficiency. BMJ 2003; 326(7386): 409–10. doi: 10.1136/bmj.326.7386.409

20.
Bhandari N, Bahl R, Taneja S, Strand T, Molbak K, Ulvik RJ, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum. BMJ 2002; 324(7350): 1358. doi: 10.1136/bmj.324.7350.1358

21.
Brown KH, Wuheler SE. Zinc and humal health: results of recent trials and impications for program interventions and research. In: Centre IDR, editor. The Micronutrient intiative. Ottawa: Micronutrient Initiative; 2000, p. 1–68.

22.
Meeks Gardner J, Witter MM, Ramdath DD. Zinc supplementation: effects on the growth and morbidity of undernourished Jamaican children. Eur J Clin Nutr 1998; 52(1): 34–9. doi: 10.1038/sj.ejcn.1600509

23.
EFSA. Tolerable upper intake levels for vitamins and minerals: European Food Safety Authority (EFSA). Scientific Committee on Food Scientific Panel on Dietetic Products, Parma: Nutrition and Allergies; 2006, 500 p.

24.
Choi S, Liu X, Pan Z. Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. Acta Pharmacol Sin 2018; 39(7): 1120–32. doi: 10.1038/aps.2018.25

25.
Cruz KJC, de Oliveira ARS, Morais JBS, Severo JS, Mendes PMV, de Sousa Melo SR, et al. Zinc and insulin resistance: biochemical and molecular aspects. Biol Trace Elem Res 2018; 186(2): 407–12. doi: 10.1007/s12011-018-1308-z

26.
Pompano LM, Boy E. Effects of dose and duration of zinc interventions on risk factors for type 2 diabetes and cardiovascular disease: a systematic review and meta-analysis. Adv Nutr 2021; 12(1): 141–60. doi: 10.1093/advances/nmaa087

27.
Sandstead HH. Zinc deficiency. A public health problem? Am J Dis Child 1991; 145(8): 853–9. doi: 10.1001/archpedi.1991.02160080029016

28.
Mayo-Wilson E, Junior JA, Imdad A, Dean S, Chan XH, Chan ES, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database Syst Rev 2014; 5: CD009384 doi: 10.1002/14651858.CD009384.pub2

29.
Gera T, Shah D, Sachdev HS. Zinc supplementation for promoting growth in children under 5 years of age in low- and middle-income countries: a systematic review. Indian Pediatr 2019; 56(5): 391–406. doi: 10.1007/s13312-019-1537-z

30.
Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68(2 Suppl): 447S–63S. doi: 10.1093/ajcn/68.2.447S

31.
Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K, Miyazaki C, et al. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev 2015; 2: CD000230 doi: 10.1002/14651858.CD000230.pub5

32.
Sandstrom B. Dose dependence of zinc and manganese absorption in man. Proc Nutr Soc 1992; 51(2): 211–8. doi: 10.1079/PNS19920031

33.
Krebs NF, Hambidge KM. Zinc requirements and zinc intakes of breast-fed infants. Am J Clin Nutr 1986; 43(2): 288–92. doi:10.1093/ajcn/43.2.288

34.
King JC. Determinants of maternal zinc status during pregnancy. Am J Clin Nutr 2000; 71(5 Suppl): 1334S–43S. doi: 10.1093/ajcn/71.5.1334s

35.
Swanson CA, King JC. Zinc utilization in pregnant and nonpregnant women fed controlled diets providing the zinc RDA. J Nutr 1982; 112(4): 697–707. doi: 10.1093/jn/112.4.697

36.
Fung EB, Ritchie LD, Woodhouse LR, Roehl R, King JC. Zinc absorption in women during pregnancy and lactation: a longitudinal study. Am J Clin Nutr 1997; 66(1): 80–8. doi: 10.1093/ajcn/66.1.80

37.
Moser-Veillon PB. Zinc needs and homeostasis during lactation. Analyst 1995; 120(3): 895–7. doi: 10.1039/an9952000895
Published
2023-12-06
How to Cite
Strand T. A., & Mathisen M. (2023). Zinc – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research, 67. https://doi.org/10.29219/fnr.v67.10368
Section
Nordic Nutrition Recommendations