Alcohol – a scoping review for Nordic Nutrition Recommendations 2023

Dag Steinar Thelle; Morten Grønbæk

doi:10.29219/fnr.v68.10540

Dag Steinar Thelle Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Morten Grønbæk National Institute of Public Health, Copenhagen, Denmark

DOI: https://doi.org/10.29219/fnr.v68.10540

Keywords: Alcohol, total mortality, cause-specific mortality, age, observational studies, Mendelian randomization, safe limit

Abstract

The objective of this scoping review is to evaluate the updated evidence on the consumption of alcohol and health outcomes regarded as relevant for the Nordic and Baltic countries, including cardiovascular disease, cancer, and all-cause mortality. It is based on the previous Nordic Nutrition Recommendations of 2012 and relevant papers published until 31 May 2021. Current evidence from mainly observational epidemiological studies suggests that regular, moderate alcohol consumption may confer protective effects against myocardial infarction (MI) and type 2 diabetes. Mendelian randomization analyses do not fully support these findings, possibly because these analyses may fail to identify low alcohol intake. For several cancers, it is not possible to set any safe limit. All-cause mortality is not increased with light to moderate alcohol intake in middle-aged and older adults who do not engage in binge drinking. Total abstinence is associated with the lowest risk of mortality in young adults. Observational studies on alcohol consumption are hampered by a number of inherent methodological issues such as ascertainment of alcohol intake, selection of appropriate exposure groups, and insufficient control of confounding variables, colliders, and mediators. It should also be emphasized that there is a socio-economic contribution to the alcohol-health axis with a stronger detrimental effect of alcohol in the lower social classes. The above issues contribute to the complexity of unravelling the causal web between alcohol, mediators, confounders, and health outcome.

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