Dietary simple sugar intake, metabolic indicators, markers of inflammation, and injury among semi-professional football players

Jun Hou; Yuemei Cui; Jun Gao; Ming Rong

doi:10.29219/fnr.v69.11036

Jun Hou Faculty of Sports Science, Ningbo University, China; Research Academy of Grand Health, Ningbo University, Ningbo, China
Yuemei Cui Research Academy of Grand Health, Ningbo University, Ningbo, China
Jun Gao Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China
Ming Rong Faculty of Sports Science, Ningbo University, China; Research Academy of Grand Health, Ningbo University, Ningbo, China

DOI: https://doi.org/10.29219/fnr.v69.11036

Keywords: simple sugar, glucose, fructose, inflammation, high-sensitivity C-reactive protein, adenosine deaminase

Abstract

Background: Dietary sugar intake has been implicated in the development of metabolic dysfunction, chronic inflammation, and immune dysfunction, contributing to the pathogenesis of various diseases. This study aimed to investigate the associations between dietary total simple sugar intake and glycemic markers, lipid profile, serum levels of high-sensitivity C-reactive protein (hs-CRP), and adenosine deaminase activity (ADA), among semi-professional football players.

Methods: A cross-sectional study was conducted among 108 semi-professional football players. Dietary intake of simple sugars was assessed using validated dietary assessment tools, while serum levels of biochemical variables were measured using standard laboratory assays. Multinomial logistic regression analysis and partial correlation analysis were performed to examine the associations between dietary simple sugars and serum biomarkers, adjusting for confounders.

Results: Strong positive associations were observed between dietary total simple sugar intake and hs-CRP and ADA levels in multinomial regression analysis. Also, among individual assessment of dietary simple sugars, dietary fructose and glucose intake were positively correlated with serum hs-CRP levels (r = 0.484, P < 0.001 and r = 0.393, P < 0.001, respectively) and serum ADA levels (r = 0.233, P = 0.001 for glucose; r = 0.188, P = 0.01 for fructose). There was no other association between dietary simple sugar intake and metabolic parameters.

Conclusion: Our findings highlight the significant impact of dietary sugar intake on inflammation, as reflected by serum hs-CRP and ADA levels. Strategies aimed at reducing sugar consumption may help mitigate inflammation and improve overall health outcomes. Further research is warranted to elucidate the underlying mechanisms and to explore potential therapeutic interventions targeting dietary sugar intake for the prevention and management of chronic diseases.

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References

1.
Spano M, Kruskall L, Thomas DT. Nutrition for sport, exercise, and health. Champaign, IL: Human Kinetics; 2023.

2.
Quintero KJ, de Sá Resende A, Leite GSF, Junior AHL. An overview of nutritional strategies for recovery process in sports-related muscle injuries. Nutrire 2018; 43(1): 27. doi: 10.1186/s41110-018-0084-z

3.
Papadopoulou SK. Rehabilitation nutrition for injury recovery of athletes: the role of macronutrient intake. Nutrients 2020; 12(8): 2449. doi: 10.3390/nu12082449

4.
Gonzalez JT, Betts JA. Dietary sugars, exercise and hepatic carbohydrate metabolism. Proc Nutr Soc 2019; 78(2): 246–56. doi: 10.1017/S0029665118002604

5.
Walberg-Rankin J. Dietary carbohydrate as an ergogenic aid for prolonged and brief competitions in sport. Int J Sport Nutr Exerc Metab 1995; 5(Suppl. 1): S13–28. doi: 10.1123/ijsn.5.s1.s13

6.
Costill DL. Carbohydrates for exercise: dietary demands for optimal performance. Int J Sports Med 1988; 9(1): 1–18. doi: 10.1055/s-2007-1024971

7.
Peinado AB, Rojo-Tirado MA, Benito PJ. [Sugar and exercise: its importance in athletes]. Nutr Hosp 2013; 28(Suppl. 4): 48–56.

8.
Brown RC. Nutrition for optimal performance during exercise: carbohydrate and fat. Curr Sports Med Rep 2002; 1(4): 222–9. doi: 10.1249/00149619-200208000-00006

9.
Hosseini-Esfahani F, Bahadoran Z, Mirmiran P, Hosseinpour-Niazi S, Hosseinpanah F, Azizi F. Dietary fructose and risk of metabolic syndrome in adults: Tehran Lipid and Glucose study. Nutr Metab 2011; 8: 1–8. doi: 10.1186/1743-7075-8-50

10.
Hawley JA, Dennis SC, Noakes TD. Oxidation of carbohydrate ingested during prolonged endurance exercise. Sports Med 1992; 14: 27–42. doi: 10.2165/00007256-199214010-00003

11.
Convertino VA, Armstrong LE, Coyle EF, Mack GW, Sawka MN, Senay LC, Jr, et al. American College of Sports Medicine position stand. Exercise and fluid replacement. Med Sci Sports Exerc 1996; 28(1): i–vii. doi: 10.1097/00005768-199610000-00045

12.
Fajstova A, Galanova N, Coufal S, Malkova J, Kostovcik M, Cermakova M, et al. Diet rich in simple sugars promotes pro-inflammatory response via gut microbiota alteration and TLR4 signaling. Cells 2020; 9(12): 2701. doi: 10.3390/cells9122701

13.
Seo EH, Kim H, Kwon O. Association between total sugar intake and metabolic syndrome in middle-aged Korean men and women. Nutrients 2019; 11(9): 2042. doi: 10.3390/nu11092042

14.
Lodge M, Scheidemantle G, Adams VR, Cottam MA, Richard D, Breuer D, et al. Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells. Sci Rep 2024; 14(1): 4020. doi: 10.1038/s41598-024-54272-w

15.
Wang Y, Qi W, Song G, Pang S, Peng Z, Li Y, et al. High-fructose diet increases inflammatory cytokines and alters gut microbiota composition in rats. Mediators Inflamm 2020; 2020: 6672636. doi: 10.1155/2020/6672636

16.
Benetti E, Mastrocola R, Rogazzo M, Chiazza F, Aragno M, Fantozzi R, et al. High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR-δ agonism. Mediators Inflamm 2013; 2013: 509502. doi: 10.1155/2013/509502

17.
Chielle EO, Granella LW, Maziero JS, Vidigal TMA, Mallmann BLK, Karal J. Evolution of potential biomarkers of acute muscle injury after physical exercise. Braz J Pharm Sci 2019; 55: e17594. doi: 10.1590/s2175-97902019000117594

18.
Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol 2005; 288(2): R345–53. doi: 10.1152/ajpregu.00454.2004

19.
Zhai L, Pan H, Cao H, Zhao S, Yao P. Reliability and validity of a semi-quantitative food frequency questionnaire: dietary intake assessment among multi-ethnic populations in Northwest China. J Health Popul Nutr 2023; 42(1): 111. doi: 10.1186/s41043-023-00452-9

20.
Li H, Li D, Wang X, Ding H, Wu Q, Li H, et al. The role of dietary patterns and dietary quality on body composition of adolescents in Chinese college. Nutrients 2022; 14(21): 4544. doi: 10.3390/nu14214544

21.
Ren YJ, Meng S, Liu QM, Tan YY, Du YK, Li LM, et al. Validation of the simplified Chinese-character version of the international physical activity questionnaire-long form in urban community-dwelling adults: a cross-sectional study in Hangzhou, China. Biomed Environ Sci 2017; 30(4): 255–63.

22.
Dickinson S, Hancock DP, Petocz P, Ceriello A, Brand-Miller J. High–glycemic index carbohydrate increases nuclear factor-κB activation in mononuclear cells of young, lean healthy subjects. Am J Clin Nutr 2008; 87(5): 1188–93. doi: 10.1093/ajcn/87.5.1188

23.
Vinapamula KS, Pemmaraju SV, Bhattaram SK, Bitla AR, Manohar SM. Serum adenosine deaminase as inflammatory marker in rheumatoid arthritis. J Clin Diagn Res 2015; 9(9): BC08. doi: 10.7860/JCDR/2015/14296.6483

24.
Ponzo V, Pellegrini M, Costelli P, Vázquez-Araújo L, Gayoso L, D’Eusebio C, et al. Strategies for reducing salt and sugar intakes in individuals at increased cardiometabolic risk. Nutrients 2021; 13(1): 279. doi: 10.3390/nu13010279

25.
Zhu Z, Luo C, Qu S, Wei X, Feng J, Zhang S, et al. Effects of school-based interventions on reducing sugar-sweetened beverage consumption among Chinese children and adolescents. Nutrients 2021; 13(6): 1862. doi: 10.3390/nu13061862