Rice bran triterpenoids improve postprandial hyperglycemia in healthy male adults: a randomized, double-blind, placebo-controlled study
Background: Compared to white rice, brown rice induces a lower glycemic response in healthy and diabetic humans. This effect is partly attributed to the higher amounts of water- or oil-soluble bran components and dietary fiber in brown rice. We hypothesized that dietary supplementation with oil-soluble rice bran triterpenoids (RBTs; triterpene alcohol and sterol prepared from rice bran) might reduce the incidence of postprandial hyperglycemia in healthy humans.
Objective: We examined the acute effects of a single RBT-supplemented meal on the postprandial blood glucose responses of healthy male adults in a double-blind, randomized, placebo-controlled, crossover trial.
Design: Nineteen subjects consumed a test meal containing either placebo- or RBT-supplemented olive oil. Blood biomarkers were evaluated in a fasting state and up to 240 min postprandially.
Results: Compared to the placebo-supplemented meal, the RBT-supplemented meal significantly suppressed the increase in postprandial blood glucose level. A subclass analysis revealed that RBT-supplemented oil significantly reduced blood glucose increases in subjects with higher postprandial blood glucose elevations. Postprandial increases in blood insulin, glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP-1) levels did not differ between the groups.
Conclusion: These results suggest that RBT consumption improves postprandial hyperglycemia in healthy humans, especially those with higher postprandial glucose increases.
- International Diabetes Federation. IDF Diabetes Atlas –8th edn. 2017. Available from: http://www.diabetesatlas.org/
- Brown A, Reynolds LR, Bruemmer D. Intensive glycemic control and cardiovascular disease: an update. Nat Rev Cardiol 2010;7:369–75. doi: 10.1038/nrcardio.2010.35
- Mannucci E, Monami M, Lamanna C, Adalsteinsson JE. Post-prandial glucose and diabetic complications: systematic review of observational studies. Acta Diabetol 2012;49:307–14. doi: 10.1007/s00592-011-0355-0
- Pillarisetti S. Potential drug combinations to reduce cardiovascular disease burden in diabetes. Trends Pharmacol Sci 2016;37:207–19. doi: 10.1016/j.tips.2015.11.009
- Takao T, Suka M, Yanagisawa H, Iwamoto Y. Impact of postprandial hyperglycemia at clinic visits on the incidence of cardiovascular events and all-cause mortality in patients with type 2 diabetes. J Diabetes Investig 2017;8:600–8. doi: 10.1111/jdi.12610
- Suades R, Cosentino F, Badimon L. Glucose-lowering treatment in cardiovascular and peripheral artery disease. Curr Opin Pharmacol 2018;39:86–98. doi: 10.1016/j.coph.2018.03.001
- Cicero AFG, Derosa G. Rice bran and its main components: potential role in the management of coronary risk factors. Curr Top Nutraceutical Res 2005;3:29–46. Available from: http://www.nchpjournals.com/journals/manuscript.php?msid=880
- Rong N, Ausman LM, Nicolosi RJ. Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids 1997;32:303–9. doi: 10.1007/s11745-997-0037-9
- Son MJ, Rico CW, Nam HS, Kang MY. Influence of oryzanol and ferulic acid on the lipid metabolism and antioxidative status in high fat-fed mice. J Clin Biochem Nutr 2010;46:150–6. doi: 10.3164/jcbn.09-98
- Akihisa T, Yasukawa K, Yamaura M, Ukiya M, Kimura Y, Shimizu N, et al. Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects. J Agric Food Chem 2000;48:2313–19. doi: 10.1021/jf000135o
- Yasukawa K, Akihisa T, Kimura Y, Tamura T, Takido M. Inhibitory effect of cycloartenolferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin. Biol Pharm Bull 1998;21:1072–6. doi: 10.1248/bpb.21.1072
- Okahara F, Suzuki J, Hashizume K, Osaki N, Shimotoyodome A. Triterpene alcohols and sterols from rice bran reduce postprandial hyperglycemia in rodents and humans. MolNutr Food Res 2016;60:1521–31. doi: 10.1002/mnfr.201500897
- Fukuoka D, Okahara F, Hashizume K, Yanagawa K, Osaki N, Shimotoyodome A. Triterpene alcohols and sterols from rice bran lower postprandial glucose-dependent insulinotropic polypeptide release and prevent diet-induced obesity in mice. J ApplPhysiol 2014;117:1337–48. doi: 10.1152/japplphysiol.00268.2014
- Yabe D, Seino Y. Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and beta cell preservation. Prog Biophys Mol Biol 2011;107:248–56. doi: 10.1016/j.pbiomolbio.2011.07.010
- Panlasigui LN, Thompson LU. Blood glucose lowering effects of brown rice in normal and diabetic subjects. Int J Food Sci Nutr 2006;57:151–8. doi: 10.1080/09637480500410879
This work is licensed under a Creative Commons Attribution 4.0 International License
Authors retain copyright of their work, with first publication rights granted to SNF Swedish Nutrition Foundation.