Intake of vitamin B12 in relation to vitamin B12 status in groups susceptible to deficiency: a systematic review

Linnea  Bärebring; Christel Lamberg-Allardt; Birna Thorisdottir; Alfons Ramel; Fredrik  Söderlund; Erik Kristoffer Arnesen; Bright I. Nwaru; Jutta Dierkes; Agneta Åkesson

doi:10.29219/fnr.v67.8626

Linnea Bärebring Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Christel Lamberg-Allardt Department of Food and Nutrition, University of Helsinki, Finland
Birna Thorisdottir Faculty of Sociology, Anthropology and Folkloristics and Health Science Institute, University of Iceland, Iceland
Alfons Ramel Faculty of Food Science and Nutrition, University of Iceland, Iceland
Fredrik Söderlund Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, the Karolinska Institute, Sweden
Erik Kristoffer Arnesen Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
Bright I. Nwaru Krefting Research Centre, Institute of Medicine, University of Gothenburg, Sweden
Jutta Dierkes Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Norway; and Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Norway
Agneta Åkesson Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, the Karolinska Institute, Sweden

DOI: https://doi.org/10.29219/fnr.v67.8626

Keywords: cobalamin, vitamin B12, holotranscobalamin, ; methylmalonic acid, homocysteine, dietary guidelines

Abstract

Objective: To systematically review the evidence for whether habitual or different levels of experimental intake of vitamin B12 from diet and supplements is sufficient to ensure adequate B12 status in groups most susceptible to vitamin B12 deficiency.

Methods: We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Scopus up to 21 May 2021, for intervention studies, prospective cohort studies and case-control studies assessing B12 intake from diet and/or supplements in relation to B12 status (s/p-B12, holotranscobalamin, methylmalonic acid, homocysteine or breastmilk B12). Cross-sectional studies were eligible for studies conducted during pregnancy and lactation. Included populations were children (0–18 years), young adults (18–35 years), pregnant or lactating women, older adults (≥65 years) and vegans or vegetarians. Study selection, data extraction and risk of bias assessment were conducted by two assessors independently. The evidence was synthesized qualitatively and classified according to the World Cancer Research Fund.

Results: The searches yielded 4855 articles of which 89 were assessed in full text and 18 included. Three studies were conducted during pregnancy and three during lactation or infancy – all observational. Eight studies were conducted among older adults; most were interventions among B12-deficient participants. Four studies were eligible for vegetarian and vegans, all interventions. The strength of evidence that habitual B12 intake or an intake in line with the current Nordic recommended intake (RI) is sufficient to ensure adequate status was considered Limited – no conclusion for all included populations.

Conclusion: Evidence is insufficient to assess if or which level of B12 intake is sufficient to maintain adequate status for all included populations. Population-based cohort studies and low-to-moderate dose interventions that address this question are highly warranted.

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Intake of vitamin B12 in relation to vitamin B12 status in groups susceptible to deficiency: a systematic review

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