Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice

Hyun Sook Lee; Young Eun Jeon; Riyo Awa; Susumu Yoshino; Eun Ji Kim

doi:10.29219/fnr.v67.9413

Hyun Sook Lee Department of Food Science & Nutrition, Dongseo University, Busan, Korea
Young Eun Jeon Industry coupled Cooperation Center for Bio Healthcare Materials, Hallym University, Chuncheon, Korea
Riyo Awa Research Center, Maruzen Pharmaceuticals Co. Ltd., Hiroshima, Japan
Susumu Yoshino Research Center, Maruzen Pharmaceuticals Co. Ltd., Hiroshima, Japan
Eun Ji Kim Hallym University

DOI: https://doi.org/10.29219/fnr.v67.9413

Keywords: Kaempferia parviflora, Anti-obesity, Adipogenic transcription factors, Adipokines, C57BL/6N mice

Abstract

Kaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adipose tissue weight, adipocyte size, and serum levels of glucose, triglycerides, cholesterol, insulin, and leptin in HFD-induced obese C57BL/6N mice. KPE inhibited adipogenesis by decreasing CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase 1, ATP-citrate lyase, and fatty acid synthase mRNA expression. KPE improved lipolysis by increasing carnitine palmitoyl transferase 1 and hormone-sensitive lipase mRNA expression. These results suggest that KPE may have inhibited HFD-induced obesity by regulating several pathways involved in decreasing adipogenesis and enhancing lipolysis. Thus, the results suggest that KPE (or KP) may be applicable as an anti-obesity agent.

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