Serum zinc reference intervals and its relationship with dietary, functional, and biochemical indicators in 6- to 9-year-old healthy children

  • Camila Xavier Alves Federal University of Rio Grande do Norte (UFRN)
  • Naira Josele Neves de Brito Federal University of Rio Grande do Norte (UFRN)
  • Karina Marques Vermeulen Federal University of Rio Grande do Norte (UFRN)
  • Márcia Marília Gomes Dantas Lopes Federal University of Rio Grande do Norte (UFRN)
  • Mardone Cavalcante França Federal University of Rio Grande do Norte (UFRN)
  • Selma Sousa Bruno Federal University of Rio Grande do Norte (UFRN)
  • Maria das Graças Almeida Federal University of Rio Grande do Norte (UFRN)
  • José Brandão-Neto Federal University of Rio Grande do Norte (UFRN)
Keywords: Zinc status, Reference interval, Biochemical indicators, Dietary indicators, Functional indicators, Young children

Abstract

Background: Zinc is an important cause of morbidity, particularly among young children. The dietary, functional, and biochemical indicators should be used to assess zinc status and to indicate the need for zinc interventions.

Objective: The purpose of this study was to determine the zinc status and reference intervals for serum zinc concentration considering dietary, functional, and biochemical indicators in apparently healthy children in the Northeast Region of Brazil.

Design: The cross-sectional study included 131 healthy children: 72 girls and 59 boys, aged between 6 and 9 years. Anthropometric assessment was made by body mass index (BMI) and age; dietary assessment by prospective 3-day food register, and an evaluation of total proteins was performed. Zinc in the serum samples was analyzed in triplicate in the same assay flame, using atomic absorption spectrophotometry.

Results: With respect to dietary assessment, only the intake of fiber and calcium was below the recommendations by age and gender. All subjects were eutrophic according to BMI and age classification. Zinc intake correlated with energy (p=0.0019), protein (p=0.0054), fat (p<0.0001), carbohydrate (p=0.0305), fiber (p=0.0465), calcium (p=0.0006), and iron (p=0.0003) intakes. Serum zinc correlated with protein intake (p=0.0145) and serum albumin (p=0.0141), globulin (p=0.0041), and albumin/globulin ratio (p=0.0043). Biochemical parameters were all within the normal reference range. Reference intervals for basal serum zinc concentration were 0.70–1.14 µg/mL in boys, 0.73–1.17 µg/mL in girls, and 0.72–1.15 µg/mL in the total population.

Conclusions: This study presents pediatric reference intervals for serum zinc concentration, considering dietary, functional, and biochemical indicators, which are useful to establish the zinc status in specific groups. In this regard, there are few studies in the literature conducted under these conditions, which make it an innovative methodology.

Keywords: zinc status; reference interval; biochemical indicators; dietary indicators; functional indicators; young children

(Published: 5 April 2016)

Citation: Food & Nutrition Research 2016, 60: 30157 - http://dx.doi.org/10.3402/fnr.v60.30157

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Author Biographies

Camila Xavier Alves, Federal University of Rio Grande do Norte (UFRN)

Department of Internal Medicine

Nutritionist, MSc

Naira Josele Neves de Brito, Federal University of Rio Grande do Norte (UFRN)

Department of Internal Medicine

Pharmaceutical, PhD

Karina Marques Vermeulen, Federal University of Rio Grande do Norte (UFRN)

Department of Internal Medicine

Nutritionist

Márcia Marília Gomes Dantas Lopes, Federal University of Rio Grande do Norte (UFRN)

Department of Internal Medicine

Nutritionist, PhD

Mardone Cavalcante França, Federal University of Rio Grande do Norte (UFRN)

Department of Statistics

Associate Professor, PhD

Selma Sousa Bruno, Federal University of Rio Grande do Norte (UFRN)

Department of Physiotherapy

Associate Professor, PhD

Maria das Graças Almeida, Federal University of Rio Grande do Norte (UFRN)

Department of Clinical and Toxicological Analyses

Associate Professor, PhD

José Brandão-Neto, Federal University of Rio Grande do Norte (UFRN)

Department of Internal Medicine

MD, PhD, Full Professor

 

Published
2016-04-05
How to Cite
1.
Alves C, de Brito NJ, Vermeulen K, Lopes MM, França M, Bruno S, Almeida M das G, Brandão-Neto J. Serum zinc reference intervals and its relationship with dietary, functional, and biochemical indicators in 6- to 9-year-old healthy children. fnr [Internet]. 2016Apr.5 [cited 2019Jun.25];600. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/1027
Section
Original Articles

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