Attenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies

  • Tsuyoshi Sadakiyo
  • Yuki Ishida
  • Shin-ichiro Inoue
  • Yoshifumi Taniguchi
  • Takeo Sakurai
  • Ryodai Takagaki
  • Mayumi Kurose
  • Tetsuya Mori
  • Akiko Yasuda-Yamashita
  • Hitoshi Mitsuzumi
  • Michio Kubota
  • Hikaru Watanabe
  • Shigeharu Fukuda
Keywords: Isomaltodextrin, soluble dietary fiber, carbohydrate loading, blood glucose, everted rat intestinal sac

Abstract

Background : Isomaltodextrin (IMD) is a novel highly branched α-glucan and its function as a soluble dietary fiber is expected.

Objective : The goal of this study was to evaluate the effects of IMD on postprandial glucose excursions in healthy people and to make the mechanism clear.

Design : Twenty-nine subjects ingested a solution containing maltodextrin (MD) or sucrose with or without IMD. Fourteen subjects ingested a solution containing glucose with or without IMD. Blood glucose concentrations were then compared between the groups. Furthermore, in vitro digestion, inhibition of digestive enzymes, and glucose absorption tests were conducted.

Results : IMD attenuated blood glucose elevation in the subjects with blood glucose excursions at the high end of normal following the ingestion of MD or sucrose or glucose alone. This effect of 5 g IMD was most clear. IMD was digested partially only by small intestinal mucosal enzymes, and maltase and isomaltase activities were weakly inhibited. Furthermore, IMD inhibited the transport of glucose from mucosal side to serosal side.

Conclusions : IMD attenuated postprandial blood glucose, after the ingestion of MD or sucrose or glucose. As one of the mechanism, it was suggested that IMD inhibited the absorption of glucose on small intestinal mucosal membrane.

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Published
2017-05-24
How to Cite
1.
Sadakiyo T, Ishida Y, Inoue S- ichiro, Taniguchi Y, Sakurai T, Takagaki R, Kurose M, Mori T, Yasuda-Yamashita A, Mitsuzumi H, Kubota M, Watanabe H, Fukuda S. Attenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies. Food & Nutrition Research [Internet]. 24May2017 [cited 19Jul.2018];61. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/1187
Section
Original Articles