Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats

  • Yao Jiang
  • Chuhan Fu
  • Guihua Liu
  • Jiao Guo
  • Zhengquan Su
Keywords: Chitosan oligosaccharide, Antihyperlipidemic, Gene Difference Expression, High-fat diet, CYP7A1, HMGCR


Background: Chitooligosaccharide (COS) has shown potential antihyperlipidemic activity in a few studies as
a functional food.

Method: We investigated the cholesterol-lowering effect and potential mechanisms of chitooligosaccharide
capsules (COSTC) in male SD rats fed a high-fat diet.

Results: COSTC could ameliorate serum lipid levels. Simultaneously, the cholesterol-lowering effect is probably
attributed to its role in two pathways: upregulating the gene expression and activity of cholesterol 7α-hydroxylase (CYP7A1), liver X receptor alpha (LXRA), and peroxisome proliferation activated receptor-α (PPARα), which facilitates the conversion of cholesterol into bile acid; downregulating the gene expression and activity of enzymes including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) and upregulating the low-density lipoprotein receptor (LDLR) to reduce the denovo synthesis of cholesterol.

Conclusion: Studies have suggested that COSTC has potential usefulness as a natural supplement or functional food for preventing and treating hyperlipidemia.


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How to Cite
Jiang Y, Fu C, Liu G, Guo J, Su Z. Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats. Food & Nutrition Research [Internet]. 14Jun.2018 [cited 20Sep.2018];62. Available from:
Original Articles