Blood biomarkers of various dietary patterns correlated with metabolic indicators in Taiwanese type 2 diabetes

  • Meng-Chuan Huang Graduate Institute of Medicine and Department of Public Health and Environmental Medicine, School of Medicine, Kaohsiung Medical University
  • Chaio-I Chang Graduate Institute of Medicine and Department of Public Health and Environmental Medicine, School of Medicine, Kaohsiung Medical University
  • Wen-Tsan Chang Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University
  • Yen-Ling Liao Graduate Institute of Medicine and Department of Public Health and Environmental Medicine, School of Medicine, Kaohsiung Medical University.
  • Hsin-Fang Chung School of Public Health, University of Queensland
  • Chih-Cheng Hsu Institute of Population Health Sciences, National Health Research Institutes
  • Shyi-Jang Shin Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University.
  • Kun-Der Lin Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University.
Keywords: dietary pattern, ferritin, n-3 PUFA, Taiwan, type 2 diabetes

Abstract

Background: Metabolic alterations correlate with adverse outcomes in type 2 diabetes. Dietary modification serves as an integral part in its treatment.

Objective: We examined the relationships among dietary patterns, dietary biomarkers, and metabolic indicators in type 2 diabetes (n = 871).

Design: Diabetic patients (n = 871) who provided complete clinical and dietary data in both 2008 and 2009 were selected from a cohort participating in a diabetic control study in Taiwan. Dietary data were obtained using a short, semiquantitative food frequency questionnaires, and dietary pattern identified by factor analysis. Multiple linear regressions were used to analyze the association between dietary biomarkers (ferritin, folate, and erythrocyte n-3 polyunsaturated fatty acids [n-3 PUFAs]) and metabolic control upon adjusting for confounders.

Results: Three dietary patterns (high-fat meat, traditional Chinese food–snack, and fish–vegetable) were identified. Ferritin correlated positively with high-fat meat factor scores (P for trend <0.001). Erythrocyte n-3 PUFAs (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], n-3/n-6 PUFA ratio) correlated positively with fish–vegetable factor scores (all P for trends <0.001). Multiple linear regressions revealed a positive relationship between ferritin concentrations and fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), and triglycerides, but a negative relationship with high-density lipoprotein cholesterol (HDL-C). Erythrocyte n-3 PUFA, EPA+DHA, and n-3/n-6 PUFA ratio were negatively linked to FPG, HbA1c, and triglycerides (all P < 0.05) and positively with HDL-C (though n-3/n-6 ratio marginally correlated).

Conclusions: Ferritin and n-3 PUFA can serve as valid biomarkers for high-fat meat and fish–vegetable dietary patterns. Unlike ferritin, erythrocyte n-3 PUFA status was related to better glycemic and blood lipid profiles. Our results suggest that habitual consumption of diet pattern rich in fish and vegetables may contribute in part to a healthier metabolic profile in type 2 diabetes.

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Author Biography

Meng-Chuan Huang, Graduate Institute of Medicine and Department of Public Health and Environmental Medicine, School of Medicine, Kaohsiung Medical University

 

 

 

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Published
2019-11-20
How to Cite
1.
Huang M-C, Chang C-I, Chang W-T, Liao Y-L, Chung H-F, Hsu C-C, Shin S-J, Lin K-D. Blood biomarkers of various dietary patterns correlated with metabolic indicators in Taiwanese type 2 diabetes. fnr [Internet]. 2019Nov.20 [cited 2019Dec.6];630. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/3592
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