Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats

  • Junbo Wang (1) Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China (2) Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Xueyuan Road 38, Haidian District, Beijing, 100191, PR China.
  • Meihong Xu
  • Rui Liang
  • Ming Zhao
  • Zhaofeng Zhang
  • Yong Li
Keywords: Metabolism, Physical activity, Human nutrition,

Abstract

Background: The goal of the present study was to investigate the wound-healing potential of marine collagen peptides (MCPs) from chum salmon skin administered to rats following cesarean section (CS).

Methods: Ninety-six pregnant Sprague-Dawley rats were randomly divided into four groups: a vehicle group and three MCP groups. After CS, rats were intragastrically given MCPs at doses of 0, 0.13, 0.38, 1.15 g/kg*bw, respectively. On postoperative days 7, 14, and 21, the uterine bursting pressure, skin tensile strength, hydroxyproline (Hyp) concentrations, and histological and immunohistochemical characteristics of the scar tissue were examined.

Results: In the MCP groups, the skin tensile strength, uterine bursting pressure, and Hyp were significantly higher than those in the vehicle group at all three time points (p<0.05). The formation of capillary, fibroblast, and collagen fiber, the expression of platelet-endothelial cell adhesion molecule-1, basic fibroblast growth factor, and transforming growth factor beta-1 were increased in the MCP groups (p<0.05).

Conclusion: MCPs could accelerate the process of wounding healing in rats after CS.

Keywords: cesarean section; marine collagen peptide; wound healing; basic fibroblast growth factor; transforming growth factor beta 1; CD31

(Published: 13 May 2015)

Citation: Food & Nutrition Research 2015, 59: 26411 - http://dx.doi.org/10.3402/fnr.v59.26411

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Published
2015-05-13
How to Cite
Wang, J., Xu, M., Liang, R., Zhao, M., Zhang, Z., & Li, Y. (2015). Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats. Food & Nutrition Research, 59. https://doi.org/10.3402/fnr.v59.26411
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Original Articles