Antiobesity effect of <em>Kaempferia parviflora</em> accompanied by inhibition of lipogenesis and stimulation of lipolysis

Seong-Hoo  Park; Jeongjin  Park; Minhee  Lee; Jinhak  Kim; Sangwon Eun; Woojin  Jun; Ok-Kyung Kim; Jeongmin  Lee

doi:10.29219/fnr.v67.9374

Seong-Hoo Park Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
Jeongjin Park Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea
Minhee Lee Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
Jinhak Kim R&D Division, Daehan Chemtech Co. Ltd. Seoul, Republic of Korea
Sangwon Eun R&D Division, Daehan Chemtech Co. Ltd. Seoul, Republic of Korea
Woojin Jun Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea
Ok-Kyung Kim Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea
Jeongmin Lee Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea

DOI: https://doi.org/10.29219/fnr.v67.9374

Keywords: lipogenesis, adipogenesis, lipolysis, Kaempferia parviflora, obesity

Abstract

Background: Obesity occurs when energy intake is excessive compared to energy expenditure, resulting in the excessive storage of triglyceride in adipose tissue.

Objective: The present study aimed to investigate the antiobesity effects of Kaempferia parviflora extracts (PF) in high-fat diet (HFD)-induced obese mice and 3T3-L1 adipocytes to demonstrate the lipid mechanisms underlying these effects.

Design: Mice were fed with a normal diet (AIN93G normal diet), HFD (60% HFD), Met (HFD containing metformin 250 mg/kg b.w.), PF50 (HFD containing PF 50 mg/kg b.w.), and PF100 (HFD containing PF 100 mg/kg b.w.) for 12 weeks.

Results: Body weight gain, adipose tissue weight, adipose tissue mass, and size of adipocytes were significantly decreased by PF supplementation in HFD-fed mice. Moreover, PF supplementation suppressed the adipogenesis and lipogenesis pathways and activated the lipolysis and thermogenesis pathways in the adipose tissues of HFD-fed mice.

Conclusions: PF treatment during the differentiation of 3T3-L1 cells suppressed adipogenesis and lipogenesis and PF treatment after differentiation activated lipolysis and thermogenesis. Thus, we suggest that PF is effective for weight loss by directly affecting the lipid metabolism of adipocytes.

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Antiobesity effect of Kaempferia parviflora accompanied by inhibition of lipogenesis and stimulation of lipolysis

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