Sunflower (Helianthus annuus) seed extract suppresses the lipogenesis pathway and stimulates the lipolysis pathway in high-fat diet-induced obese mice

  • Jeong Moon Yun Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
  • Jaeeun Jung Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
  • Seong-Hoo Park Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
  • Young Ha Seo Rpbio Co. Ltd. 634, Seoul, Republic of Korea
  • Jae Kyoung Lee Rpbio Co. Ltd. 634, Seoul, Republic of Korea
  • Mun Hyoung Bae Rpbio Co. Ltd. 634, Seoul, Republic of Korea
  • Sangwon Eun R&D Division, Daehan Chemtech Co. Ltd., Seoul, Republic of Korea
  • Ok-Kyung Kim Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea
  • Jeongmin Lee Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea; and Research Institute of Clinical Nutrition, Kyung Hee University, Seoul, Republic of Korea
Keywords: obesity; sunflower seed; lipolysis; adipogenesis; lipogenesis


Background: Obesity, abnormal fat accumulation in the adipose tissue, has become a serious global public health problem as it increases an individual’s risk of developing various diseases.

Objective: This study sought to determine whether the extract from sunflower seed (SUNCA) prevents the development of obesity in high-fat diet (HFD)-induced obese mice.

Design: C57BL/6J mice were fed with AIN93G normal diet (Normal diet), 60% HFD, HFD containing Catechin 100 mg/kg body weight (b.w.) (Catechin), HFD containing SUNCA 25 mg/kg b.w. (SUNCA 25), HFD containing SUNCA 50 mg/kg b.w. (SUNCA 50), or HFD containing SUNCA 100 mg/kg b.w. (SUNCA 100) for 15 weeks.

Results: Body weight gain, food efficiency rate, adipose tissue weight, adipose tissue mass, size of adipocytes, and serum levels of triglyceride, total cholesterol, very low-density lipoprotein/low-density lipoprotein (VLDL/LDL)-cholesterol, aspartate aminotransferase, and alanine aminotransferase were significantly decreased by SUNCA supplementation in HFD-fed mice. Furthermore, SUNCA supplementation decreased the expression of proteins related to the adipogenesis and lipogenesis pathways and increased the expression of proteins related to the lipolysis and thermogenesis pathways in the adipose tissues of HFD-induced obese mice.

Conclusions: Altogether, SUNCA might prevent obesity by suppressing the adipogenesis/lipogenesis pathway and stimulating the lipolysis/thermogenesis pathway in HFD-induced obese mice.


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How to Cite
Yun J. M., Jung J., Park S.-H., Seo Y. H., Lee J. K., Bae M. H., Eun S., Kim O.-K., & Lee J. (2022). Sunflower (<em>Helianthus annuus</em&gt;) seed extract suppresses the lipogenesis pathway and stimulates the lipolysis pathway in high-fat diet-induced obese mice. Food & Nutrition Research, 66.
Original Articles