Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation

  • Seong-Hoo Park Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
  • Sun-jung Baek Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
  • Minhee Lee Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
  • Hyun-A Shin ACROM CO., LTD. Suwon, Republic of Korea
  • Hye jin Lee ACROM CO., LTD. Suwon, Republic of Korea
  • Ok-Kyung Kim Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Republic of Korea
  • Jeongmin Lee Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea
DOI: https://doi.org/10.29219/fnr.v68.10180
Keywords: obesity, lipolysis, lipogenesis, olive, rosemary, black bean

Abstract

Background: Obesity is characterized by an imbalance between energy intake and expenditure, leading to the excessive accumulation of triglycerides in adipose tissue.

Objective: This study investigated the potential of Oxylia to prevent obesity in mice fed with a high-fat diet (HFD).

Design: C57BL/6J mice were fed with one of the following five diets – AIN93G normal diet (normal control), 60% (HFD; control), HFD containing metformin at 40 mg/kg body weight (b.w.) (Met; positive control), HFD containing Oxylia at 30 mg/kg b.w. (O30), or HFD containing Oxylia at 60 mg/kg b.w. (O60) – for 15 weeks.

Results: Mice under an HFD supplemented with Oxylia had decreased body weight gain, adipose tissue weight, and adipose tissue mass. In addition, triglyceride (TG), total cholesterol, and VLDL/LDL cholesterol levels were lower in the O60 groups than in the HFD-fed control group. Moreover, Oxylia supplementation decreased the expression of adipogenesis-related mRNAs and lipogenesis-related proteins while increasing the expression of lipolysis-related proteins in white adipose tissue and thermogenesis-related proteins in brown adipose tissue.

Conclusions: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.

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Published
2024-03-12
How to Cite
Park S.-H., Baek S.- jung, Lee M., Shin H.-A., Lee H. jin, Kim O.-K., & Lee J. (2024). Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation. Food & Nutrition Research, 68. https://doi.org/10.29219/fnr.v68.10180
Issue
Vol 68 (2024)
Section
Original Articles
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