Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

  • Ji Hye Kim
  • Ok-Kyung Kim
  • Ho-Geun Yoon
  • Jeongjin Park
  • Yanghee You
  • Kyungmi Kim
  • Yoo-Hyun Lee
  • Kyung-Chul Choi
  • Jeongmin Lee
  • Woojin Jun
Keywords: Curcuma longa, high-fat diet, adipogenesis, lipolysis, anti-obesity

Abstract

Background: Even though Curcuma longa L. possesses various biological activities, it has strong flavor and taste, which decrease consumer palatability and limit industrial applications in food.

Objective: The present study investigates the effects of C. longa L. fermented with Aspergillus oryzae supplementation in 60% high-fat diet-induced obese rats measured by the activation of adipogenesis and lipolysis.

Design: Rats were divided into four groups (n=6 per group) after 1 week of acclimatization: a normal diet group comprised rats fed the AIN76A rodent diet; a high-fat diet-induced obese group with rats fed a 60% high-fat diet; a Garcinia cambogia treated group (positive control) with rats fed a 60% high-fat diet with G. cambogia 500 g/kg body weight (b.w.)/day; and an fermented C. longa L. 50% ethanolic extract treated group (FCE50) with rats fed a 60% high-fat diet with FCE50 500 g/kg b.w./day. Each group received the appropriate vehicle or sample daily by gastric intubation for 12 weeks.

Results: We found that FCE50 administration suppressed b.w. gain and reduced white adipose tissue weight, serum triglyceride (TG), and cholesterol in high-fat diet-induced obese rats. These results can be associated with the suppression of adipocyte differentiation and lipogenesis with a decrease in the mRNA expressions of fatty acid synthase, acetyl-CoA carboxylase, adipocyte protein 2, and lipoprotein lipase induced by FCE50 administration. In addition, FCE50 increased lipolysis and β-oxidation by up-regulating the expression of lipases such as adipose triglyceride lipase, hormone-sensitive lipase, adiponectin, and AMP-activated protein kinase.

Conclusions: These results suggest that FCE50 can be a candidate for the prevention of obesity via suppressing adipogenesis and promoting lipolysis.

Keywords: Curcuma longa; high-fat diet; adipogenesis; lipolysis; anti-obesity

(Published: 27 January 2016)

Citation: Food & Nutrition Research 2016, 60: 30428 - http://dx.doi.org/10.3402/fnr.v60.30428

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Published
2016-01-27
How to Cite
1.
Kim JH, Kim O-K, Yoon H-G, Park J, You Y, Kim K, Lee Y-H, Choi K-C, Lee J, Jun W. Anti-obesity effect of extract from fermented <em>Curcuma longa</em&gt; L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. fnr [Internet]. 2016Jan.27 [cited 2019May24];600. Available from: https://foodandnutritionresearch.net/index.php/fnr/article/view/1055
Section
Original Articles